The prevalence and mortality rates of severe infections are high in intensive care units
(ICUs). At the same time, the high pharmacokinetic variability observed in ICU patients …

Background The effect of renal replacement therapy on drug concentrations in patients with
sepsis has not been fully elucidated because the pharmacokinetic properties of many …

Various studies have reported insufficient beta-lactam concentrations in critically ill patients.
The optimal dosing strategy for beta-lactams in critically ill patients, particularly in septic …

Background We analyzed the attainment of early pharmacological targets of continuous
infusion meropenem and piperacillin/tazobactam and the use and effect of a real-time …

Introduction Meropenem bactericidal activity depends on the time when the free drug
concentrations remain above the minimum inhibitory concentration of pathogens. The goal …

This study was a pharmacokinetic (PK)–pharmacodynamic (PD) target attainment analysis
of meropenem in Japanese adult patients. Plasma drug concentration data (265 samples …

Critically ill patients are characterized by substantial pathophysiological changes that alter
the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is …

Background The pharmacokinetics (PK) of antibiotics change during sepsis and continuous
renal replacement therapies in critically ill patients. Limited evidence exists on the use of the …

Extended infusion (EI) administration of β-lactams can improve target attainment in critically
ill patients with altered pharmacokinetics/pharmacodynamics. To optimize meropenem …

Objective Meropenem is a β-lactam, carbapenem antibacterial agent with antimicrobial
activity against gram-negative, gram-positive and anaerobic micro-organisms and is …