Outer membrane protein A inhibits the degradation of caspase-1 to regulate NLRP3 inflammasome activation and exacerbate the Acinetobacter baumannii pulmonary …

Y Li, C Peng, D Zhao, L Liu, B Guo, M Shi, Y Xiao… - Microbial …, 2021 - Elsevier
Abstract Acinetobacter baumannii (A. baumannii), one of the major pathogens that causes
severe nosocomial infections, is characterised by a high prevalence of drug resistance. It …

[HTML][HTML] NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection

N Dikshit, SD Kale, HJ Khameneh, V Balamuralidhar… - Mucosal …, 2018 - Elsevier
The opportunistic Gram-negative bacterium Acinetobacter baumannii (AB) is a leading
cause of life-threatening nosocomial pneumonia. Outbreaks of multidrug resistant (MDR)-AB …

[HTML][HTML] Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264. 7 …

Z An, J Su - Microbes and Infection, 2019 - Elsevier
Acinetobacter baumannii (A. baumannii) is a Gram-negative bacterium, which acts as an
opportunistic pathogen and causes hospital-acquired pneumonia and bacteremia by …

Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains

FJ Li, L Starrs, A Mathur, H Ishii, SM Man, G Burgio - Plos one, 2022 - journals.plos.org
Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen with growing
clinical significance globally. A. baumannii has an exceptional ability to rapidly develop drug …

NLRP3 inflammasome mediates interleukin‐1β production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in …

MJ Kang, SG Jo, DJ Kim, JH Park - Immunology, 2017 - Wiley Online Library
Acinetobacter baumannii is a multi‐drug resistant, Gram‐negative bacteria and infection
with this organism is one of the major causes of mortality in intensive care units …

Aeromonas sobria Induces Proinflammatory Cytokines Production in Mouse Macrophages via Activating NLRP3 Inflammasome Signaling Pathways

W Zhang, Z Li, H Yang, G Wang, G Liu… - Frontiers in Cellular …, 2021 - frontiersin.org
Aeromonas sobria, a common conditional pathogenic bacteria, is widely distributed in the
environment and causes gastroenteritis in humans or septicemia in fish. Of all Aeromonas …

Pseudomonas aeruginosa triggers macrophage autophagy to escape intracellular killing by activation of the NLRP3 inflammasome

Q Deng, Y Wang, Y Zhang, M Li, D Li… - Infection and …, 2016 - Am Soc Microbiol
Assembly of the inflammasome has recently been identified to be a critical event in the
initiation of inflammation. However, its role in bacterial killing remains unclear. Our study …

Acinetobacter baumannii Outer Membrane Protein A Induces Pulmonary Epithelial Barrier Dysfunction and Bacterial Translocation Through The TLR2/IQGAP1 Axis

W Zhang, H Zhou, Y Jiang, J He, Y Yao… - Frontiers in …, 2022 - frontiersin.org
Pulmonary epithelial barrier dysfunction is a critical pathophysiological process in
pneumonia and associated invasive infections, such as those caused by Acinetobacter …

P. aeruginosa biofilm activates the NLRP3 inflammasomes in vitro

Q Tan, Q Ai, Y He, F Li, J Yu - Microbial Pathogenesis, 2022 - Elsevier
The ability of P. aeruginosa to form biofilms renders common treatments inefficient, thereby
promoting chronic infection. Inflammasomes activate caspase-1, which is important for the …

[HTML][HTML] Necroptosis signaling and NLRP3 inflammasome cross-talking in epithelium facilitate Pseudomonas aeruginosa mediated lung injury

H Li, J Guan, J Chen, W Sun, H Chen, Y Wen… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Pseudomonas aeruginosa induced acute lung injury is such a serious risk to public health,
but the pathological regulation remains unclear. Here, we reported that PA mediated …