Bioengineering immune cells via gene therapy offers treatment opportunities for currently
fatal viral infections. Also cell therapeutics offer most recently a breakthrough technology to …

Because of physicochemical similarities between siRNA and DNA and their overlapping
barriers to delivery, many approaches for siRNA delivery have utilized the same materials as …

In this study, we use modified cationic nanocarriers as vehicles for the intracellular delivery
of therapeutic siRNA. After developing nanocarrier formulations with appropriate pKa, size …

Background: Cancer poses a major public health issue, is linked with high mortality rates
across the world, and shows a strong interplay between genetic and environmental factors …

RNA interference-based therapies are dependent on intracellular delivery of siRNA. The
release of siRNA from the endosomal compartment may be a rate limiting step in the …

Short interfering RNA (siRNA) functions directly in the cytoplasm, where it is assembled into
an RNA‐induced silencing complex (RISC). The localized delivery of siRNA to a specific site …

RNA interference (RNAi) technology has been a promising treatment strategy for combating
intractable diseases. However, the applications of RNAi in clinical are hampered by …

ABSTRACT Introduction: Small interfering RNA (siRNA) is an effective method for regulating
the expression of proteins, even “undruggable” ones that are nearly impossible to target …

With the dearth of effective treatment options for prominent diseases including Ebola and
cancer, RNA interference (RNAi), a sequence‐specific mechanism for genetic regulation …

T lymphocytes are the major drivers of antitumor immunity. The recent clinical success of
adoptive T cell therapies and immune checkpoint inhibitors has demonstrated the strength of …