Background: Colorectal carcinoma (CRC) is the most common neoplasm of the
gastrointestinal tract. COX-2 plays an important role in CRC development and is a key target …

Background: The aim of this study was to evaluate cyclooxygenase-2 (COX-2)
immunoreactivity in colorectal adenocarcinomas and to find correlations with different …

The aim of this study was to evaluate expression of COX-1 in renal cell carcinoma (RCC)
and its prognosticvalue. mRNA of COX-1 was detected in 42 paired RCC and adjacent …

AIM: Recent clinical epidemiological studies have demonstrated the preventive effect of non-
steroidal anti-inflammatory drugs (NSAIDs) against colorectal cancer. The underlying …

Background: Cyclooxygenase 2 (COX-2) is important as an enzyme in the pathway leading
to the production of prostaglandin E2 (PGE2) and arachidonic acid. This pathway is known …

Abstract Background Cyclooxygenase-2 (COX-2, PTGS2) is an enzyme involved in the
synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes …

Background Increased cyclooxygenase activity promotes progression of colorectal cancer,
but the mechanisms behind COX-2 induction remain elusive. This study was therefore …

Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs
(NSAIDs), known to inhibit cyclooxygenase (COX), reduce the risk of colorectal cancer. COX …

Purpose Cyclooxygenase (COX)-2 is an inducible isoform responsive to cytokines,
mitogens, and growth factors, and is believed to be an important enzyme related to …

Abstract Background and Objectives Epidemiological studies have suggested that the
regular use of nonsteroidal antiinflammatory drugs, which inhibit cyclooxygenase (COX) …