Sustainable and reproducible large animal models that closely replicate the clinical
sequelae of myocardial infarction (MI) are important for the translation of basic science …

Introduction of newly discovered cardiovascular therapeutics into first-in-man trials depends
on a strictly regulated ethical and legal roadmap. One important prerequisite is a good …

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Despite enormous efforts in treating myocardial infarction (MI) and subsequent heart failure,
the recent statistics from the American Heart Association evidently show that there still …

Mouse models are a valuable tool for studying acute injury and chronic remodeling of the
myocardium in vivo. With the advent of genetic modifications to the whole organism or the …

INTRODUCTION: Progress in cardiovascular regenerative medicine research requires the
availability of appropriate experimental animal models that are as close to humans as …

Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

With heart failure leading the cause of death in the USA (Hunt), biomedical research is
fundamental to advance medical treatments for cardiovascular diseases. Animal models that …

Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Animal models of cardiovascular pathology contribute towards understanding and treatment
of a broad range of conditions. Specifically in the context of acute myocardial infarction …