Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6
S Haertter - Drug metabolism and drug interactions, 2013 - degruyter.com
Abstract The cytochrome P450 2D6 (CYP2D6) belongs to a group of CYPs considered of
utmost importance in the metabolism of xenobiotics. Despite being of only minor abundance …
utmost importance in the metabolism of xenobiotics. Despite being of only minor abundance …
Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates
The metabolic activity of the polymorphic CYP2D6 enzyme is dependent on the CYP2D6
genotype; however, the guidelines for translating the genotype into phenotype, which are of …
genotype; however, the guidelines for translating the genotype into phenotype, which are of …
Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution
D Marez, M Legrand, N Sabbagh… - Pharmacogenetics …, 1997 - journals.lww.com
The polymorphic cytochrome P450 CYP2D6 is involved in the metabolism of various drugs
of wide therapeutic use and is a presumed susceptibility factor for certain environmentally …
of wide therapeutic use and is a presumed susceptibility factor for certain environmentally …
PharmVar GeneFocus: CYP2D6
C Nofziger, AJ Turner, K Sangkuhl… - Clinical …, 2020 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
[HTML][HTML] Will pharmacogenomics guide clinical practice?
Very seldom has a field been launched at a more auspicious time. Pharmacogenomics
emerged as the sequencing of the human genome was nearly complete, as DNA arrays …
emerged as the sequencing of the human genome was nearly complete, as DNA arrays …
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity
M Ingelman-Sundberg - The pharmacogenomics journal, 2005 - nature.com
CYP2D6 is of great importance for the metabolism of clinically used drugs and about 20–
25% of those are metabolised by this enzyme. In addition, the enzyme utilises …
25% of those are metabolised by this enzyme. In addition, the enzyme utilises …
Importance of CYP2D6 genotype/activity testing and applications
JAG Agúndez, E García-Martin - 2014 - Taylor & Francis
The potential of pharmacogenomic biomarkers has been extensively investigated in recent
years. Because polymorphisms in genes coding for drug-metabolizing enzymes are a major …
years. Because polymorphisms in genes coding for drug-metabolizing enzymes are a major …
Availability of CYP2D6 Genotyping Results in General Practitioner and Community Pharmacy Medical Records
M Simoons, H Mulder, RA Schoevers, HG Ruhé… - …, 2017 - Taylor & Francis
Aim: To investigate the availability of CYP450–2D6 (CYP2D6) genotyping results in general
practitioner (GP) and/or community pharmacy records, and the influence thereof on …
practitioner (GP) and/or community pharmacy records, and the influence thereof on …
CYP2D6 polymorphism in a Gabonese population: contribution of the CYP2D6*2 and CYP2D6*17 alleles to the high prevalence of the intermediate metabolic …
Panserat, Sica, Gérard, Mathieu… - British journal of …, 1999 - Wiley Online Library
Aims To determine the molecular basis of the intermediate extensive metaboliser (EM)
CYP2D6 phenotype in healthy Gabonese subjects. Methods The CYP2D6 phenotype of 154 …
CYP2D6 phenotype in healthy Gabonese subjects. Methods The CYP2D6 phenotype of 154 …
[HTML][HTML] Allele drop out conferred by a frequent CYP2D6 genetic variation for commonly used CYP2D6* 3 genotyping assays
G Scantamburlo, K Tziolia, M Zopf… - Cellular physiology and …, 2017 - karger.com
Background/Aim: Accurate genotyping of CYP2D6 is challenging due to its inherent genetic
variation, copy number variation (duplications and deletions) and hybrid formation with …
variation, copy number variation (duplications and deletions) and hybrid formation with …