Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort
TM Dodgen, CDJ Labuschagne… - The …, 2016 - nature.com
The relationship between genetic variation in CYP2D6 and variable drug response
represents a potentially powerful pharmacogenetic tool. However, little is known regarding …
represents a potentially powerful pharmacogenetic tool. However, little is known regarding …
Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese …
K Fukunaga, E Hishinuma, M Hiratsuka… - Journal of human …, 2021 - nature.com
Next-generation sequencing (NGS) has identified variations in cytochrome P450 (CYP) 2D6
associated with drug responses. However, determination of novel haplotypes is difficult …
associated with drug responses. However, determination of novel haplotypes is difficult …
[HTML][HTML] Common mutant alleles of CYP2D6 causing the defect of CYP2D6 enzyme activity in a Japanese population
A Ishiguro, T Kubota, H Sasaki… - British journal of clinical …, 2003 - ncbi.nlm.nih.gov
CYPD2D6, an isoform of cytochrome P450 catalysing more than 50 clinically important
drugs, is highly polymorphic. There are important interethnic differences in the frequencies …
drugs, is highly polymorphic. There are important interethnic differences in the frequencies …
[HTML][HTML] Recommendations for clinical CYP2D6 genotyping allele selection: a joint consensus recommendation of the Association for Molecular Pathology, College of …
VM Pratt, LH Cavallari, AL Del Tredici… - The Journal of Molecular …, 2021 - Elsevier
The goals of the Association for Molecular Pathology Clinical Practice Committee's
Pharmacogenomics (PGx) Working Group are to define the key attributes of …
Pharmacogenomics (PGx) Working Group are to define the key attributes of …
Polymorphisms of CYP2C19 and CYP2D6 in Israeli Ethnic Groups
HR Luo, V Aloumanis, KM Lin, D Gurwitz… - American Journal of …, 2004 - Springer
Background The cytochrome P450 isoenzymes CYP2C19 and CYP2D6 catalyze reactions
involved in the metabolism of many widely used drugs. Their polymorphisms give rise to …
involved in the metabolism of many widely used drugs. Their polymorphisms give rise to …
CYP2D6 Phenotyping Using Urine, Plasma, and Saliva Metabolic Ratios to Assess the Impact of CYP2D6∗10 on Interindividual Variation in a Chinese Population
R Chen, X Zheng, P Hu - Frontiers in Pharmacology, 2017 - frontiersin.org
Purpose: Asian populations have around 40–60% frequency of reduced function allele
CYP2D6∗ 10 compared to 1–2% in Caucasian populations. The wide range of CYP2D6 …
CYP2D6∗ 10 compared to 1–2% in Caucasian populations. The wide range of CYP2D6 …
Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
EU Griese, UM Zanger, U Brudermanns… - Pharmacogenetics …, 1998 - journals.lww.com
The polymorphic cytochrome P450 CYP2D6 catalyses the biotransformation of at least 40
drugs. The CYP2D6 genetic polymorphism is responsible for pronounced interindividual …
drugs. The CYP2D6 genetic polymorphism is responsible for pronounced interindividual …
Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity
D Wang, MJ Poi, X Sun, A Gaedigk… - Human molecular …, 2014 - academic.oup.com
Abstract Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of 25% of clinically
used drugs. Genetic polymorphisms cause substantial variation in CYP2D6 activity and …
used drugs. Genetic polymorphisms cause substantial variation in CYP2D6 activity and …
Discovery of the nonfunctional CYP2D6*31 allele in Spanish, Puerto Rican, and US Hispanic populations
A Gaedigk, M Isidoro-García, RE Pearce… - European journal of …, 2010 - Springer
Abstract Background CYP2D6* 31 (4042G> A, R 440 H) is an allelic variant of the highly
polymorphic cytochrome P450 2D6 enzyme that has been associated with reduced …
polymorphic cytochrome P450 2D6 enzyme that has been associated with reduced …
How to integrate CYP2D6 phenoconversion into clinical pharmacogenetics: a tutorial
EJ Cicali, AL Elchynski, KJ Cook… - Clinical …, 2021 - Wiley Online Library
CYP2D6 genotype is increasingly being integrated into practice to guide prescribing of
certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by …
certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by …