Distinct phenotype and function of circulating Vδ1+ and Vδ2+ γδT-cells in acute and chronic hepatitis B

KM Chang, D Traum, JJ Park, S Ho, K Ojiro… - PLoS …, 2019 - journals.plos.org
Hepatitis B virus (HBV) persists with global and virus-specific T-cell dysfunction, without T-
cell based correlates of outcomes. To determine if γδT-cells are altered in HBV infection …

Increased Frequencies of Circulating IFN-γ-Producing Vδ1+ and Vδ2+ γδ T Cells in Patients with Asymptomatic Persistent Hepatitis B Virus Infection

MJ Conroy, R Mac Nicholas, M Taylor, S O'Dea… - Viral …, 2015 - liebertpub.com
Hepatitis B virus (HBV) is a leading cause of liver cirrhosis and hepatocellular carcinoma.
The outcome of HBV infection is largely determined by the host immune response, with virus …

Enhanced peripheral γδT cells cytotoxicity potential in patients with HBV-associated acute-on-chronic liver failure might contribute to the disease progression

M Chen, P Hu, H Peng, W Zeng, X Shi, Y Lei… - Journal of clinical …, 2012 - Springer
Background The current study explored the characteristics of γδ T cells in the blood of HBV-
associated acute-on-chronic liver failure (HBV-ACLF) patients and examined the …

Activated γδ T cells exhibit cytotoxicity and the capacity for viral clearance in patients with acute hepatitis B

ZH Jia, YY Li, JY Wang, JY Zhang, A Huang, XD Guo… - Clinical …, 2019 - Elsevier
Abstract γδ T cells are a unique population of lymphocytes that have regulatory roles in
patients with chronic hepatitis B (CHB); however, their role in acute hepatitis B (AHB) …

[HTML][HTML] Diverse functions of γδ T cells in the progression of hepatitis B virus and hepatitis C virus infection

W Hou, X Wu - Frontiers in Immunology, 2021 - frontiersin.org
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are primary risk factors for a
wide spectrum of liver diseases that severely affect human health. The liver is an …

Enhanced Functions of Peripheral γδ T Cells in Chronic Hepatitis B Infection during Interferon α Treatment In Vivo and In Vitro

M Chen, P Hu, N Ling, H Peng, Y Lei, H Hu, D Zhang… - PloS one, 2015 - journals.plos.org
Background γδ T cells play an important role in infectious, autoimmune, or neoplastic
diseases. Here, a study was conducted to investigate the dynamic changes in phenotype …

Decreased Vδ2 γδ T cells associated with liver damage by regulation of Th17 response in patients with chronic hepatitis B

X Wu, JY Zhang, A Huang, YY Li… - The Journal of …, 2013 - academic.oup.com
Background. γδ T cells comprise a small subset of T cells and play a protective role against
cancer and viral infections; however, their precise role in patients with chronic hepatitis B …

Functional dichotomy of Vδ2 γδ T cells in chronic hepatitis C virus infections: role in cytotoxicity but not for IFN-γ production

W Yin, S Tong, Q Zhang, J Shao, Q Liu, H Peng… - Scientific Reports, 2016 - nature.com
Vδ2 γδ (Vδ2) T cells, a major human γδ T cell subset, exhibit broad anti-tumor and anti-
infective activity; however, their precise role in chronic hepatitis C virus (HCV) infections …

Increase in liver γδ T cells with concurrent augmentation of IFN‑β production during the early stages of a mouse model of acute experimental hepatitis B virus infection

L Chang, L Wang, N Ling… - Experimental and …, 2020 - spandidos-publications.com
The role of γδ T cells in acute hepatitis B virus (HBV) infection remains unclear. For the
present study, a mouse model of acute HBV infection was constructed using hydrodynamic …

Characteristics of Circulating T Cell Receptor γδ T Cells from Individuals Chronically Infected with Hepatitis B Virus (HBV): An Association between Vδ2 Subtype and …

M Chen, D Zhang, W Zhen, Q Shi, Y Liu… - The Journal of …, 2008 - academic.oup.com
Background. To date, few studies have been conducted to determine whether T cell receptor
(TCR) γδ T cells are involved in hepatitis B virus (HBV) infection. This study was performed …