Proteasome machinery is a major proteostasis control system in human cells, actively
compensated upon its inhibition. To understand this compensation, we compared global …

Proteasome inhibition is used therapeutically to induce proteotoxic stress and trigger
apoptosis in cancer cells that are highly dependent on the proteasome. As a mechanism of …

Proteasomes are multi-subunit complexes that specialize in protein degradation. Cancer
cells exhibit a heightened dependence on proteasome activity, presumably to support their …

In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces
new proteasome synthesis promoted by the transcription factor RPN4. This ensures that …

In response to proteasome dysfunction, mammalian cells upregulate proteasome gene
expression by activating Nrf1. Nrf1 is an endoplasmic reticulum-resident transcription factor …

Proteasomes are essential protease complexes that maintain cellular homeostasis, and
aberrant proteasomal activity supports cancer development. The regulatory mechanisms …

Accumulating evidence has revealed that human cancers develop by sequentially mutating
pivotal genes, including driver genes, and acquiring cancer hallmarks. For instance, cancer …

Protein quality control is an important component of survival for all cells. The use of
proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally …

The ability to sense proteasome insufficiency and respond by directing the transcriptional
synthesis of de novo proteasomes is a trait that is conserved in evolution and is found in …

Proteasome inhibitors have been actively tested as potential anticancer drugs and in the
treatment of inflammatory and autoimmune diseases. Unfortunately, cells adapt to survive in …