The transcriptional factor Nrf1 (NF-E2-related factor 1) sustains protein homeostasis
(proteostasis) by regulating the expression of proteasome genes. Under physiological …

The ubiquitin-proteasome system and autophagy are crucially important for proteostasis in
cells. These pathways are interdependent, and dysfunction in either pathway causes …

Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …

Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular
function, transcription of proteasome subunit genes is induced in response to proteasome …

Cancer cells show heightened dependency on the proteasome for their survival, growth, and
spread. Proteasome dysregulation is therefore commonly selected in favor of the …

The proteasome is a well-identified therapeutic target for cancer treatment. It acts as the
main protein degradation system in the cell and degrades key mediators of cell growth …

The proteasome degrades most cellular proteins in a controlled and tightly regulated
manner and thereby controls many processes, including cell cycle, transcription, signalling …

An elevated proteasome activity contributes to tumorigenesis, particularly by providing
cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still …

Aggrephagy, the aggresome‑related protein degradation system, represents a protective
cellular response to shuttle misfolded proteins into the microtubule‑organizing center for …

The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular
pathways of misfolded or damaged protein degradation that maintain cellular proteostasis …