Maintenance of protein homeostasis is a crucial process for the normal functioning of the
cell. The regulated degradation of proteins is primarily facilitated by the ubiquitin …

Proteasome inhibitors are an important class of chemotherapeutic drugs. In this study, we
performed a large-scale ubiquitylome analysis of the three proteasome inhibitors MG132 …

The proteasome is the central component of the main cellular protein degradation pathway.
During the past four decades, the critical function of the proteasome in numerous …

The 26 S proteasome recognizes thousands of appropriate protein substrates in eukaryotic
cells through attached ubiquitin chains and uses its adenosine triphosphatase (ATPase) …

During protein quality control, proteotoxic misfolded proteins are recognized by molecular
chaperones, ubiquitylated by dedicated quality control ligases and delivered to the 26S …

Simple Summary To decipher the molecular mechanism underlying the resistance of a
significant fraction of mantle cell lymphoma (MCL) patients to the first-in-class proteasome …

Protein homeostasis is essential for life in eukaryotes. Organisms respond to proteotoxic
stress by activating heat shock transcription factors (HSFs), which play important roles in …

Increased proteotoxic stress (IPTS) resulting from the increased production or decreased
removal of abnormally folded proteins is recognized as an important pathogenic factor for a …

A functional ubiquitin proteasome pathway (UPP) is vital for all eukaryotic cellular systems
and therefore any alteration in this critical component of proteostasis machinery has …

Misfolded proteins and insoluble aggregates are continuously produced in the cell and can
result in severe stress that threatens cellular fitness and viability if not managed effectively …