Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …

Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …

Parental health or exposures can affect the lifetime health outcomes of offspring,
independently of inherited genotypes. Such 'epigenetic'effects occur over a broad range of …

Recent evidence demonstrates important maternal effects on an offspring's risk of
developing metabolic disease. These effects extend across the full range of maternal …

The early-life environment, in particular maternal diet during pregnancy, influences a wide
range of organs and systems in adult offspring. Mounting evidence suggests that …

The early-life developmental environment is instrumental in shaping our overall adult health
and well-being. Early-life diet and endocrine exposure may independently, or in concert with …

It has long been understood that the pathogenesis of complex diseases such as diabetes
includes both genetic and environmental components. More recently, it has become clear …

According to the developmental origins of health and disease hypothesis, in utero
experiences reprogram an individual for immediate adaptation to gestational perturbations …

Research investigating the early programming of adult metabolic disease has in recent
years provided much mechanistic insight into how the early environment impacts on long …

We are in the midst of unparalleled epidemics of obesity and type 2 diabetes—complex
phenotypes originating at the intersection of genetic and environmental risk. As detailed in …