Autoimmune diseases (ADs) are currently treated with anti‐inflammatory and
immunosuppressive drugs, aimed at reducing symptoms of disease in order to improve …

Background: Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-
dependent cellular interactions. Its upregulation on macrophages in autoimmune disease …

Virtually all cells and extracellular material are heavily decorated by various glycans, yet our
understanding of the structure and function of these moieties lags behind the understanding …

Siglecs are sialic acid-binding immunoglobulin-like lectins. Most Siglecs function as
transmembrane receptors mainly expressed on blood cells in a cell type-specific manner …

Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …

All mammalian cells display a diverse array of glycan structures that differ from those that are
found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin …

Abstract Objective Type I interferon (IFN) plays a pivotal role in the pathogenesis of systemic
lupus erythematosus (SLE) and is therefore considered a potential therapeutic target. This …

Tremendous progress has been seen in the study of the role of sialic acid binding im-
munoglobulin type lectins (Siglecs) in osteoimmunology in the past two decades. Interest in …

Autoimmune diseases affect tens of millions of people just in the United States alone. Most
of the available treatment options are aimed at reducing symptoms but do not lead to cures …

Background The molecular heterogeneity of autoimmune and inflammatory diseases has
been one of the main obstacles to the development of safe and specific therapeutic options …