How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?

N Azimi, J Mariner, S Jacobson… - AIDS research and …, 2000 - liebertpub.com
HTLV-1 is the etiological agent of a neurological disease named HAM/TSP that has clinical
characteristics similar to those of multiple sclerosis (MS). The PBMC obtained from …

Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a …

N Azimi, S Jacobson, T Leist… - The Journal of …, 1999 - journals.aai.org
Human T lymphotropic virus type I (HTLV-I) is the causative agent of an inflammatory
neurological disease termed HTLV-I-associated myelopathy/tropical spastic paraparesis …

Th17/IL-17 Axis in HTLV-1-associated myelopathy tropical spastic Paraparesis and multiple sclerosis: novel insights into the immunity during HAMTSP

M Shafiei, SH Mozhgani - Molecular Neurobiology, 2023 - Springer
Human T lymphotropic virus–associated myelopathy/tropical spastic paraparesis
(HTLV/TSP), also known as HTLV-associated myelopathy/tropical spastic paraparesis …

Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1

SB Santos, AF Porto, AL Muniz, T Luna… - …, 2007 - karger.com
Objective: Human T lymphotropic virus-type 1 (HTLV-1) activates the immune system
leading to a persistent and exacerbated T-cell response with increased production of IFN-γ …

HTLV-I-induced T-cell activation

GJ Buckle, DA Hafler, P Höllsberg - JAIDS Journal of Acquired …, 1996 - journals.lww.com
Infection by the human T-cell lymphotropic virus type I (HTLV-I) causes T-cell activation by at
least two separate mechanisms. One mechanism involves activation of the T cells harboring …

Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I–associated neurologic …

Y Enose-Akahata, U Oh, C Grant… - Blood, The Journal of …, 2008 - ashpublications.org
CD8+ T cells contribute to central nervous system inflammation in human T-cell
lymphotropic virus type I (HTLV-I)–associated myelopathy/tropical spastic paraparesis …

Genes Related to Antiviral Activity, Cell Migration, and Lysis Are Differentially Expressed in CD4+ T Cells in Human T Cell Leukemia Virus Type 1-Associated …

MT Pinto, TM Malta, ES Rodrigues… - AIDS research and …, 2014 - liebertpub.com
Human T cell leukemia virus type 1 (HTLV-1) was the first human retrovirus isolated. 1 HTLV-
1 is the etiologic agent of HTLV-1-associated myelopathy/tropical spastic paraparesis …

Increased HTLV Type 1 Tax Specific CD8+ Cells in HTLV Type 1-Asociated Myelopathy/Tropical Spastic Paraparesis: Correlation with HTLV Type 1 Proviral Load

R Kubota, M Nagai, T Kawanishi, M Osame… - AIDS research and …, 2000 - liebertpub.com
Less than 1% of individuals infected with the human T lymphotropic virus type 1 (HTLV-1)
develop an inflammatory neurological disorder, termed HTLV-1-associated …

Blockade of IL-2 receptor suppresses HTLV-I and IFN-γ expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

N Fukushima, Y Nishiura, T Nakamura, S Kohno… - Internal …, 2007 - jstage.jst.go.jp
Objective: Th1 activation based on a high HTLV-I proviral load is one of the characteristic
immunological abnormalities in the peripheral blood lymphocytes of patients with HTLV-I …

Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression

S Sarkis, G Belrose, JM Peloponese Jr, S Olindo… - Journal of Clinical …, 2013 - Elsevier
Abstract Background HTLV-1-associated myelopathy/tropical spastic paraparesis
(HAM/TSP) is a neurological inflammatory disease associated with a predominant infiltration …