[HTML][HTML] Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis

H Vietzen, SM Berger, LM Kühner, PL Furlano, G Bsteh… - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a demyelinating disease of the CNS. Epstein-Barr virus (EBV)
contributes to the MS pathogenesis because high levels of EBV EBNA 386–405-specific …

Attenuated immune control of Epstein–Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA‐DR15

H Zdimerova, A Murer, C Engelmann… - European journal of …, 2021 - Wiley Online Library
Abstract Immune responses to Epstein–Barr virus (EBV) infection synergize with the main
genetic risk factor HLA‐DRB1* 15: 01 (HLA‐DR15) to increase the likelihood to develop the …

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

JD Lünemann, I Jelčić, S Roberts… - The Journal of …, 2008 - rupress.org
Symptomatic primary Epstein-Barr virus (EBV) infection and elevated humoral immune
responses to EBV are associated with an increased risk of developing multiple sclerosis …

Epstein-Barr virus and multiple sclerosis: interaction with HLA

E Sundqvist, P Sundström, M Lindén, AK Hedström… - Genes & …, 2012 - nature.com
Epstein-Barr virus (EBV) infection, history of infectious mononucleosis (IM) and HLA-A and
DRB1 have all been proposed as risk factors for multiple sclerosis (MS). Our aim was to …

Epstein-Barr virus as a driver of multiple sclerosis

LM Sollid - Science Immunology, 2022 - science.org
Accumulating evidence implicates Epstein-Barr virus (EBV) as an etiological factor in
multiple sclerosis (MS). If EBV is a “driver” that causes antiviral immunity with associated …

Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis

MP Pender, PA Csurhes, JM Burrows… - Clinical & …, 2017 - Wiley Online Library
Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in
the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by …

The enigmatic role of viruses in multiple sclerosis: molecular mimicry or disturbed immune surveillance?

J Geginat, M Paroni, M Pagani, D Galimberti… - Trends in …, 2017 - cell.com
Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous system
(CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections promote …

Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection

AK Hedström - Frontiers in Immunology, 2023 - frontiersin.org
Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for
multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV …

Epstein-Barr virus infection of human brain microvessel endothelial cells: a novel role in multiple sclerosis

C Casiraghi, K Dorovini-Zis, MS Horwitz - Journal of neuroimmunology, 2011 - Elsevier
Multiple sclerosis (MS) is an inflammatory neurological disease that is widely regarded as
the outcome of complex interactions between a genetic predisposition and an environmental …

Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …