[HTML][HTML] Oxidative stress induces meiotic defects of oocytes in a mouse psoriasis model
ZQ Zhang, SB Tang, YY Jiang, FY Long, F He… - Cell Death & …, 2022 - nature.com
Psoriasis, an immune-mediated inflammatory disease, is associated with poor pregnancy
outcomes. Emerging evidence indicates that these defects are likely attributed to …
outcomes. Emerging evidence indicates that these defects are likely attributed to …
Melatonin protects against maternal diabetes-associated meiotic defects by maintaining mitochondrial function
XQ Li, Y Wang, SJ Yang, Y Liu, X Ma, L Liu… - Free Radical Biology …, 2022 - Elsevier
Maternal diabetes has been widely reported to adversely affect oocyte quality. Although
various molecules and pathways may be involved in this process, strategies to prevent …
various molecules and pathways may be involved in this process, strategies to prevent …
[HTML][HTML] Melatonin improves the quality of maternally aged oocytes by maintaining intercellular communication and antioxidant metabolite supply
H Zhang, C Li, D Wen, R Li, S Lu, R Xu, Y Tang, Y Sun… - Redox Biology, 2022 - Elsevier
In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …
coupling is crucial for the growth and development of competent oocytes as it mediates the …
Melatonin prevents oocyte deterioration due to cotinine exposure in mice
J Cheng, P Mi, Y Li, Y Lu, F Sun - Biology of Reproduction, 2022 - academic.oup.com
Levels of cotinine, a major metabolite of nicotine, have been positively correlated with risks
of cigarette smoking-related diseases. Melatonin is synthesized by the pineal gland and has …
of cigarette smoking-related diseases. Melatonin is synthesized by the pineal gland and has …
Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1
Y Guo, J Sun, S Bu, B Li, Q Zhang, Q Wang, D Lai - Cell Cycle, 2020 - Taylor & Francis
Chronic stress which is common in the current society can be harmful to female reproduction
and is associated with oocyte defects. However, the underlying mechanisms remain largely …
and is associated with oocyte defects. However, the underlying mechanisms remain largely …
[HTML][HTML] The boosting effects of melatonin on the expression of related genes to oocyte maturation and antioxidant pathways: a polycystic ovary syndrome-mouse …
F Nikmard, E Hosseini, M Bakhtiyari, M Ashrafi… - Journal of Ovarian …, 2022 - Springer
Background Melatonin, as a free radical scavenger exhibiting genomic actions, regulates
the antioxidant genes expression and apoptosis mechanisms. In polycystic ovary syndrome …
the antioxidant genes expression and apoptosis mechanisms. In polycystic ovary syndrome …
Melatonin protects against defects induced by deoxynivalenol during mouse oocyte maturation
M Lan, J Han, MH Pan, X Wan, ZN Pan… - Journal of Pineal …, 2018 - Wiley Online Library
Deoxynivalenol (DON) is one of the most prevalent fusarium mycotoxins in feedstuff and
food. DON causes detrimental effects on human and animal reproductive systems by …
food. DON causes detrimental effects on human and animal reproductive systems by …
[HTML][HTML] Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes
M Zhang, Y Lu, Y Chen, Y Zhang, B Xiong - Redox biology, 2020 - Elsevier
Age-related decline in female fertility is a common feature that occurs in the fourth decade of
women as a result of a reduction in both oocyte quality and quantity [1]. However, strategies …
women as a result of a reduction in both oocyte quality and quantity [1]. However, strategies …
Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end‐joining repair
Mammalian oocytes remain arrested at the first prophase of meiosis in ovarian follicles for
an extended period. During this protracted arrest, oocytes are remarkably susceptible to the …
an extended period. During this protracted arrest, oocytes are remarkably susceptible to the …
Melatonin restores the declining maturation quality and early embryonic development of oocytes in aged mice
J Qu, H Hu, H Niu, X Sun, Y Li - Theriogenology, 2023 - Elsevier
With increase in women's age, the reproductive capability of female mammals decreases
dramatically caused by age-related oxidative stress, coinciding with the decline in the …
dramatically caused by age-related oxidative stress, coinciding with the decline in the …