[HTML][HTML] Transcriptional modulation of human endogenous retroviruses in primary CD4+ T cells following vorinostat treatment
CH White, N Beliakova-Bethell, SM Lada… - Frontiers in …, 2018 - frontiersin.org
The greatest obstacle to a cure for HIV is the provirus that integrates into the genome of the
infected cell and persists despite antiretroviral therapy. A “shock and kill” approach has been …
infected cell and persists despite antiretroviral therapy. A “shock and kill” approach has been …
The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of …
MB Lucera, CA Tilton, H Mao, C Dobrowolski… - Journal of …, 2014 - Am Soc Microbiol
Latently infected cells remain a primary barrier to eradication of HIV-1. Over the past decade,
a better understanding of the molecular mechanisms by which latency is established and …
a better understanding of the molecular mechanisms by which latency is established and …
Cellular gene modulation of HIV-infected CD4 T cells in response to serial treatment with the histone deacetylase inhibitor vorinostat
JW Maxwell, SD Falcinelli, A Nefedov… - Journal of …, 2020 - Am Soc Microbiol
Histone deacetylase inhibitors (HDACi) are the most widely studied HIV latency-reversing
agents (LRAs). The HDACi suberoylanilide hydroxamic acid (vorinostat [VOR]) has been …
agents (LRAs). The HDACi suberoylanilide hydroxamic acid (vorinostat [VOR]) has been …
[HTML][HTML] Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells
Recent efforts to cure human immunodeficiency virus type-1 (HIV-1) infection have focused
on developing latency reversing agents as a first step to eradicate the latent reservoir. The …
on developing latency reversing agents as a first step to eradicate the latent reservoir. The …
[HTML][HTML] Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
JH Elliott, F Wightman, A Solomon, K Ghneim… - PLoS …, 2014 - journals.plos.org
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
[HTML][HTML] Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency
NM Archin, JL Kirchherr, JAM Sung… - The Journal of …, 2017 - Am Soc Clin Investig
BACKGROUND. The histone deacetylase (HDAC) inhibitor vorinostat (VOR) can increase
HIV RNA expression in vivo within resting CD4+ T cells of aviremic HIV+ individuals …
HIV RNA expression in vivo within resting CD4+ T cells of aviremic HIV+ individuals …
[HTML][HTML] Human endogenous retrovirus (HERV) expression is not induced by treatment with the histone deacetylase (HDAC) inhibitors in cellular models of HIV-1 …
T Hurst, M Pace, A Katzourakis, R Phillips… - Retrovirology, 2016 - Springer
Background While antiretroviral therapies have improved life expectancy and reduced viral
loads in HIV-1-positive individuals, the cessation of treatment results in a rebound of viral …
loads in HIV-1-positive individuals, the cessation of treatment results in a rebound of viral …
[HTML][HTML] Broad activation of latent HIV-1 in vivo
K Barton, B Hiener, A Winckelmann… - Nature …, 2016 - nature.com
The 'shock and kill'approach to cure human immunodeficiency virus (HIV) includes
transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) …
transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) …
[HTML][HTML] Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations …
DG Wei, V Chiang, E Fyne, M Balakrishnan… - PLoS …, 2014 - journals.plos.org
Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a
major obstacle to curing HIV infection. Pharmacological activation of HIV expression in …
major obstacle to curing HIV infection. Pharmacological activation of HIV expression in …
[HTML][HTML] Vorinostat renders the replication-competent latent reservoir of human immunodeficiency virus (HIV) vulnerable to clearance by CD8 T cells
JA Sung, K Sholtis, J Kirchherr, JD Kuruc, CL Gay… - …, 2017 - thelancet.com
Latently human immunodeficiency virus (HIV)-infected cells are transcriptionally quiescent
and invisible to clearance by the immune system. To demonstrate that the latency reversing …
and invisible to clearance by the immune system. To demonstrate that the latency reversing …