Physiological maturity is a gradual process taking place throughout infancy and childhood.
Though for years anatomical growth has been the basis for dose calculation in pediatric …

Children are not small adults because besides size there are subtle physiological and
biochemical differences between children and adults. Like adults, children also require …

Background: Physiological‐based pharmacokinetic models have been used to describe
midazolam clearance (CL) maturation. There are no maturation descriptors of CL from …

Although midazolam is a frequently used sedative in neonatal intensive care units, its use in
preterm neonates has been off‐label. Recently, a new dosing advice for midazolam for …

Background and objective Major changes in cytochrome P450 (CYP) 3A activity may be
expected in the first few months of life with, later, relatively limited changes. In this analysis …

To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of
midazolam in preterm neonates, a physiological population pharmacokinetic model was …

Objective To describe the pharmacokinetics of midazolam, a water‐soluble benzodiazepine
with a short half‐life, in critically ill neonates. Hypothesis Midazolam clearance is reduced in …

Midazolam (MDZ) is used for sedation in surgical procedures; its clinical effect is related to
its receptor affinity and the dose administered. Therefore, a pharmacokinetic …

Among pediatric patients, preterm neonates and newborns are the most vulnerable
subpopulation. Rapid developmental changes of physiological factors affecting the …

Aims To characterize the pharmacokinetics and metabolism of oral midazolam in 15 preterm
infants. Methods After an oral dose (0.1 mg kg− 1), blood was drawn up to 24 h after …