Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …

Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …

Antibiotics are among the most utilized drugs in pediatrics. Nonetheless, there is a lack in
pharmacokinetics information for this population, and dosing criteria may vary between …

The selection of the right antibiotic and right dose necessitates clinicians understand the
contribution of pharmacokinetic variability stemming from age‐related physiologic …

Purpose With a decreasing supply of antibiotics that are effective against the pathogens that
cause sepsis, it is critical that we learn to use currently available antibiotics optimally …

Introduction: For safe and effective neonatal antibiotic therapy, knowledge of the
pharmacokinetic parameters of antibacterial agents in neonates is a prerequisite. Fast …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

Background Pharmacokinetic (PK) data underlying paediatric penicillin dosing remain
limited, especially in critical care. Objectives The primary objective of the Neonatal and …

Optimal pharmacotherapy in pediatric patients with suspected infections requires
understanding and integration of relevant data on the antibiotic, bacterial pathogen, and …

Antibiotics are often used in neonates despite the absence of relevant dosing information in
drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and …