Background Myotonic dystrophies (DM) are multi-systemic diseases characterized by
muscle weakness and myotonia. Despite a growing appreciation for the cardiovascular …

Background Myotonic dystrophy (MD) types 1 and 2 frequently are associated with
progressive conduction disease. Furthermore, patients are at risk ventricular arrhythmias …

The multisystemic aspects of the disease require a multidisciplinary approach for some
patients, most likely even including state-of-the-art cardiac and brain imaging to detect and …

Objectives This study aimed to identify electrocardiographic (ECG) predictors of a prolonged
His-ventricular (HV) interval in patients with type 1 myotonic dystrophy (DM1). Background …

Abstract Myotonic dystrophy type 1 (DM1) is associated with both skeletal and cardiac
muscle involvement. The aim of the present study was to determine whether familial …

Myotonic Dystrophy type 1 (DM1) is an autosomal dominant neuromuscular disorder
characterized by progressive muscle weakness and cardiac involvement. Routine cardiac …

Background: There is limited data on the causes and predictors of mortality in patients (pts)
with myotonic dystrophy type 1 (DM1) evaluated and treated with modern medical therapy in …

Methods| The source cohort is a Johns Hopkins Hospital institutional review board–
approved prospective open cohort of consecutive patients with MMD referred to the …

So far, myotonic dystrophy (DM) has been linked to two distinct loci: DM1, associated with an
abnormal CTG triplet expansion in the 3'-untranslated region of the myotonin-protein kinase …