Background Unsatisfactory responses to major depressive disorder (MDD) therapeutics
available necessitated up-to-date treatment approaches. This study sought to investigate the …

Objective: To establish the therapeutic effect profile of sertraline in major depression. It was
hypothesized that the antidepressant effect of sertraline showed three phases: Phase 1 …

Objectivel-theanine, an amino acid uniquely contained in green tea (Camellia sinensis), has
been suggested to have various psychotropic effects. This study aimed to examine whether l …

Sertraline has been shown to be effective in the treatment of depression. However, the
relationship between the dosage of sertraline and its efficacy and safety are unclear. We …

In a 6-week, randomized, double-blind, multicenter trial, sertraline 50 mg, 100 mg, or 200
mg, or placebo, was administered once daily to 369 patients with DSM-III—defined major …

The objective of this double-blind, placebo-controlled, multicentre randomized withdrawal
study was to evaluate the efficacy and tolerability of sertraline for 16 weeks in treating …

Background: New medications that enter the marketplace have been tested almost
exclusively in controlled clinical trials conducted in specialty research settings. There is …

Purpose The aim of this study was to assess the efficacy and safety of sertraline compared
with placebo in a good clinical practice trial conducted with major depressive disorder …

In a double-blind multicentre study of outpatients with DSM-III-R major depressive disorder,
129 sertraline and 129 placebo patients were evaluated over a 6-week period. Sertraline …

Major depression is one of the most common medical disorders seen in primary care
practice. Management frequently fails to meet recommended standards of treatment. For …