Sialylated glycan structures are known for their immunomodulatory capacities and their
contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal …

Cancers utilize glycans to evade the immune system via the Sialic acid (Sia)-Siglec (Sialic-
acid-binding immunoglobulin-like lectins) pathway. Specifically, atypical structural forms of …

Over four decades ago, specific tumor characteristics were ascribed to the increased
expression of sialic acid sugars on the surface of cancer cells, and this led to the definition of …

Aberrant glycosylation is a key mechanism employed by cancer cells to evade immune
surveillance, induce angiogenesis and metastasis, among other hallmarks of cancer. Sialic …

Sialic acid sugars on the surface of cancer cells have emerged as potent immune
modulators that contribute to the immunosuppressive microenvironment and tumor immune …

Abstract Changes in glycosylation during tumour progression are a key hallmark of cancer.
One of the glycan moieties generally overexpressed in cancer are sialic acids, which can …

Immune checkpoint blockade (ICB) has substantially improved the prognosis of patients with
cancer, but the majority experiences limited benefit, supporting the need for new therapeutic …

Cancer exploits different mechanisms to escape T-cell immunosurveillance, including
overexpression of checkpoint ligands, secretion of immunosuppressive molecules, and …

Cell surface glycosylation is dynamic and often changes in response to cellular
differentiation under physiological or pathophysiological conditions. Altered glycosylation on …

Simple Summary Hyperglycosylated cancer cells are often decorated with abundant sialic
acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) …