Belimumab: review of use in systemic lupus erythematosus

EG Boyce, BE Fusco - Clinical therapeutics, 2012 - Elsevier
BACKGROUND: Belimumab, a monoclonal antibody that inhibits B-lymphocyte stimulating
protein, was the first biologic agent approved for, and the first drug approved in 55 years for …

Safety and efficacy of belimumab to treat systemic lupus erythematosus in academic clinical practices

JS Hui-Yuen, A Reddy, J Taylor, X Li… - The Journal of …, 2015 - jrheum.org
Objective. To evaluate the use and efficacy of belimumab in academic practices. Belimumab
is a human monoclonal antibody that inhibits soluble B lymphocyte stimulator and has been …

Safety of belimumab in adult patients with systemic lupus erythematosus: Results of a large integrated analysis of controlled clinical trial data

DJ Wallace, T Atsumi, M Daniels, A Hammer… - Lupus, 2022 - journals.sagepub.com
Objectives Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that
affects multiple organ systems. Belimumab, a targeted human monoclonal antibody, binds to …

Belimumab in systemic lupus erythematosus: a perspective review

JS Hui-Yuen, XQ Li… - Therapeutic Advances in …, 2015 - journals.sagepub.com
Belimumab (Benlysta®) is a fully humanized monoclonal antibody that inhibits B-lymphocyte
stimulator (also known as B cell activating factor of the tumor necrosis factor family) and was …

Long‐term safety and efficacy of belimumab in patients with systemic lupus erythematosus: a continuation of a seventy‐six–week phase III parent study in the United …

RA Furie, DJ Wallace, C Aranow… - Arthritis & …, 2018 - Wiley Online Library
Objective We undertook this US multicenter continuation study (GlaxoSmithKline study BEL
112233; ClinicalTrials. gov identifier: NCT 00724867) to assess long‐term safety and …

Belimumab in the management of systemic lupus erythematosus–an update

V Tesar, Z Hruskova - Expert opinion on biological therapy, 2017 - Taylor & Francis
Introduction: Belimumab is a fully humanised mAb against B lymphocyte stimulator (B-LyS).
It is the first biological drug licensed and approved by the US FDA and the European …

Efficacy and safety of intravenous belimumab in Japanese patients with systemic lupus erythematosus: a subgroup analysis of a phase 3 randomized placebo …

Y Tanaka, D Bass, M Chu, S Egginton, B Ji… - Modern …, 2019 - academic.oup.com
Objectives: To assess the efficacy and safety of intravenous (IV) belimumab plus standard
systemic lupus erythematosus (SLE) therapy standard of care (SoC) in Japanese patients …

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

SV Navarra, RM Guzmán, AE Gallacher, S Hall… - The Lancet, 2011 - thelancet.com
Background Systemic lupus erythematosus is a heterogeneous autoimmune disease that is
associated with B-cell hyperactivity, autoantibodies, and increased concentrations of B …

Belimumab: A step forward in the treatment of systemic lupus erythematosus

R Depascale, M Gatto, M Zen, F Saccon… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction: Systemic Lupus Erythematosus (SLE) is a chronic B cell-mediated
autoimmune disease which can potentially involve several organs and systems. The …

Update on belimumab for the management of systemic lupus erythematosus

PMK Lutalo, DP D'Cruz - Expert Opinion on Biological Therapy, 2014 - Taylor & Francis
Introduction: Belimumab is a fully humanised mAb against B lymphocyte stimulator (B-LyS).
It is the first biological drug to be licensed and approved by the US FDA and the European …