Recent advances highlight the pivotal role of nicotinamide adenine dinucleotide (NAD+) in
ovarian aging. However, the roles of de novo NAD+ biosynthesis on ovarian aging are still …

Loss of follicles together with decreased oocyte quality and quantity contribute to age-
associated ovarian senescence and infertility. Although underlying mechanisms for ovarian …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

Abstract Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox
reactions, is closely associated with age-related functional degeneration and metabolic …

Postovulatory aging would occur to impair the oocyte quality in a timedependent manner if
ovulated oocytes are not fertilized within the optimal timing in the oviduct or in the dishes …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

Advanced maternal age is highly associated with a decline in oocyte quality, but effective
approaches to improve it have still not been fully determined. Here, we report that in vivo …

Mammalian female reproductive lifespan is typically significantly shorter than life expectancy
and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms …

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial
DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate …

Maternal obesity is associated with multiple adverse reproductive outcomes, whereas the
underlying molecular mechanisms are still not fully understood. Here, we found the reduced …