Publisher Summary This chapter describes the advantages of interstitial drug delivery to the
central nervous system (CNS) using controlled release polymers. It discusses the possibility …

Malignancies of the central nervous system represent a formidable challenge and prognosis
of patients remains dismal. Physiological barriers impede efficacious delivery of tumoricidal …

Intracranial controlled release polymers have been used for drug delivery to the brain,
bypassing the blood brain barrier (BBB). By understanding the rates and patterns of …

Interstitial chemotherapy with controlled release polymers is a clinical adjunct in the
management of malignant gliomas. The need for polymer to release the chemotherapeutic …

New approaches to malignant glioma are being actively investigated. Local drug delivery
directly to the site of the tumor is one novel approach that has been approved by the US FDA …

The controlled local delivery of antineoplastic agents by biodegradable polymers is a
technique that allows for exposure of tumor cells to therapeutic doses of an active agent for …

The therapy of brain tumors has been limited by a lack of effective methods of drug delivery
to the brain. Systemic administration is often associated with toxic side effects and ultimately …

Recent advances in the treatment of malignant brain tumours have focused on the
development of targeted local delivery of therapeutic agents, which combine various …

Local delivery of chemical agents for brain tumors has offered improved prognosis for
patients with brain tumors in recent years. Agents of local delivery are highly desired for their …

The delivery of drugs to the brain has been a major challenge to the scientist developing
drugs designed for central nervous system (CNS) activity. One of the obstacles to the …