Septic shock can be defined as sepsis with persisting hypotension and is required for
vasopressors after initial unsuccessful fluid resuscitation. Elevated lactate is a biomarker of …

Hyperlactatemia is very common in patients with sepsis and septic shock and is closely
associated with poor prognosis. The third international consensus definition for sepsis and …

Early aggressive hemodynamic resuscitation using elevated plasma lactate as a marker is
an essential component of managing critically ill patients. Therefore, measurement of blood …

Recent reports have shown that oxygen delivery (D˙ o 2) and oxygen uptake (V˙ o 2) could
be related to outcome of critically ill patients. In this study, we examined measurements of …

Increased blood lactate concentration (hyperlactatemia) and lactic acidosis (hyperlactatemia
and serum pH< 7.35) are common in patients with severe sepsis or septic shock and are …

Blood lactate concentration predicts mortality in critically ill patients and is clinically used in
the diagnosis, grading of severity, and monitoring response to therapy of septic shock. This …

A fundamental objective of septic shock resuscitation is rapid restoration of tissue perfusion.
However, one of the most crucial unresolved challenges is to identify a clinical physiological …

Background: Increased plasma lactate levels in patients with sepsis may be due to
insufficient oxygen delivery, but mitochondrial dysfunction or accelerated glycolysis may …

Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen
supply/demand and/or oxygen use. Discriminating between these two mechanisms may be …

Elevations in blood lactate concentrations have been studied in sepsis and other disease
states for decades and are well known to be associated with increased mortality. Many …