Balance in the body9s hormonal axes depends on feedback onto neuroendocrine
hypothalamic neurons. This phenomenon involves transcriptional and biosynthetic effects …

Tuberoinfundibular dopamine (TIDA) neurons are the central regulators of prolactin (PRL)
secretion. Their extensive functional plasticity allows a change from low PRL secretion in the …

Neuroendocrine tuberoinfundibular dopamine (TIDA) neurons tonically inhibit pituitary
release of the hormone, prolactin. Through the powerful actions of prolactin in promoting …

The pituitary hormone, prolactin, triggers lactation in nursing mothers. Under nonlactating
conditions, prolactin secretion is suppressed by powerful inhibition from hypothalamic …

Dopamine (DA) released from the hypothalamus tonically inhibits pituitary lactotrophs. DA
(at micromolar concentration) opens potassium channels, hyperpolarizing the lactotrophs …

The relationship between neuronal impulse activity and neurotransmitter release remains
elusive. This issue is especially poorly understood in the neuroendocrine system, with its …

Milk production in the nursing mother is induced by the hormone prolactin. Its release from
the anterior pituitary is generally under tonic inhibition by neuroendocrine tuberoinfundibular …

In many tissues, including brain, prolactin action is predominantly mediated by the Janus
kinase/signal transducer and activator of transcription (STAT) signal transduction pathway …

The output of prolactin (PRL) is highly dynamic with dramatic changes in its secretion from
the anterior pituitary gland depending on prevailing physiological status. In adult female …

Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a
sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons …