Without acetylcholine (ACh) no skeletal muscle contraction, no preganglionic sympathetic or
parasympathetic activity can be obtained. This can result in dysregulation of cardiac …

The acetylcholine nicotinic receptor is an ionic channel whose aperture is directly controlled
by acetylcholine. It is a key molecule in the chemical communication between nerve cells …

Alzheimer's disease is a complex disorder affecting multiple neurotransmitters. In particular,
the degenerative progression is associated with loss within the cholinergic systems. It …

The focus of this CTBN volume aims to provide an overview of cholinergic systems in
relation to their effects on behavior and disease. Our intent was to organize a broad series of …

Phylogenetically, acetylcholine is an ancient neurochemical. Therefore, it is not surprising
that cholinergic neurons project extensively throughout the central nervous system …

Advances in our understanding of the structure, function and distribution of nicotinic
acetylcholine receptors in the CNS have provided the impetus for new studies examining the …

Nicotinic acetylcholine receptors are ligand-gated ion channels present in muscle and brain.
These allosteric oligomers may exist in several conformational states which include a resting …

In the CNS, nicotinic acetylcholine receptors prominent roles in modulating presynaptic and
postsynaptic signaling and have been implicated in several CNS disorders including the two …

Nicotinic acetylcholine receptors (AChR) are key molecules that mediate chemical
communications between cells in various parts of the body: at the neuromuscular junction, in …

Different effects of normal aging on muscarinic and nicotinic receptor subtypes were
observed in postmortem brain tissue from different regions of the human brain. A significant …