Neuronal nicotinic receptors are attracting increasing interest, beyond their role in relation to
tobacco use, in the areas of human brain aging and disorders associated with dementia. Of …

This review summarises the expression and function of muscarinic acetylcholine receptors
(mAChR) in the organism, and the therapeutic implications of recent patents on cholinergic …

The biological role of acetylcholine and the cholinergic system has been revisited within the
last decades. Acetylcholine and the pivotal components of the cholinergic system (high …

The nicotinic receptor at the nerve muscle synapse of vertebrates mediates the fast synaptic
actions of the chemical transmitter acetylcholine. This receptor was the first ligand-gated …

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in the mammalian central
nervous system (CNS). Despite this, very little was known, until recently, about their …

The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …

The importance of muscarinic synapses in the central nervous system is well-known. Potent
toxins such as atropine, known to the ancient Romans, block acetylcholine binding to its …

During the last decade, brain nicotinic acetylcholine receptors were extensively
characterized from electrophysiological and pharmacological points of view. These …

A review of studies on nicotinic cholinergic receptors in human brain is presented. The
paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies …

The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability throughout the
nervous system by acting on both the cys-loop ligand-gated nicotinic ACh receptor channels …