Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis

JD Lünemann, N Edwards, PA Muraro, S Hayashi… - Brain, 2006 - academic.oup.com
Epidemiological studies consistently demonstrate that patients with multiple sclerosis are
almost universally infected with Epstein–Barr virus (EBV) and that the risk of developing the …

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

JD Lünemann, I Jelčić, S Roberts… - The Journal of …, 2008 - rupress.org
Symptomatic primary Epstein-Barr virus (EBV) infection and elevated humoral immune
responses to EBV are associated with an increased risk of developing multiple sclerosis …

Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis

MP Pender, PA Csurhes, JM Burrows… - Clinical & …, 2017 - Wiley Online Library
Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in
the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by …

Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis

S Jilek, M Schluep, P Meylan, F Vingerhoets… - Brain, 2008 - academic.oup.com
Epstein-Barr virus (EBV) has been associated with multiple sclerosis (MS), however, most
studies examining the relationship between the virus and the disease have been based on …

Epstein-Barr virus and multiple sclerosis

JD Lünemann, C Münz - Current neurology and neuroscience reports, 2007 - Springer
Epstein-Barr virus (EBV) is one of the most common and successful human viruses, infecting
more than 90% of the world's adult population. Despite its strong tumorigenic potential, most …

[HTML][HTML] Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis

T Schneider-Hohendorf, LA Gerdes… - Journal of Experimental …, 2022 - rupress.org
Epstein–Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-
reactive antibodies might link EBV infection to CNS autoimmunity. As an altered anti-EBV T …

Epstein-Barr virus in multiple sclerosis

BA Bagert - Current neurology and neuroscience reports, 2009 - Springer
Recent seroepidemiologic and pathologic evidence suggests that prior infection with
Epstein-Barr virus (EBV) may be necessary for the development of multiple sclerosis (MS) …

Altered CD8+ T cell responses to selected Epstein–Barr virus immunodominant epitopes in patients with multiple sclerosis

P Höllsberg, HJ Hansen, S Haahr - Clinical & Experimental …, 2003 - academic.oup.com
An increased frequency of antiviral CD8+ T cells is seen in chronic viral infections. During
herpes virus infections the expanded CD8+ T cells are thought to control the reactivation of …

Epstein–Barr virus and multiple sclerosis: potential opportunities for immunotherapy

MP Pender, SR Burrows - Clinical & translational immunology, 2014 - Wiley Online Library
Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the
central nervous system (CNS) causing progressive disability. Many observations implicate …

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model

NR Jog, MT McClain, LD Heinlen, T Gross… - Journal of …, 2020 - Elsevier
Multiple sclerosis (MS) is an autoimmune demyelinating disease with progressive
neurodegeneration and complex etiology likely involving genetic and environmental factors …