DNA methylation of NR3C1 and FKBP5 is associated with posttraumatic stress disorder, posttraumatic growth, and resilience.
O Miller, J Shakespeare-Finch, D Bruenig… - … , Practice, and Policy, 2020 - psycnet.apa.org
Objective: Understandings of the biological mechanisms underpinning posttrauma
responses are limited. This pilot study aimed to expand research in this area by examining …
responses are limited. This pilot study aimed to expand research in this area by examining …
A systematic review of DNA methylation and gene expression studies in posttraumatic stress disorder, posttraumatic growth, and resilience
Most people will experience a traumatic event within their lifetime. One commonly
recognized response to trauma exposure is posttraumatic stress disorder (PTSD). The …
recognized response to trauma exposure is posttraumatic stress disorder (PTSD). The …
Allele-specific DNA methylation level of FKBP5 is associated with post-traumatic stress disorder
Abstract Background FK506-binding protein 5 (FKBP5) binds to glucocorticoid receptors and
modulates glucocorticoid sensitivity. The FKBP5 gene has been implicated in the …
modulates glucocorticoid sensitivity. The FKBP5 gene has been implicated in the …
Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder
Background. Epigenetic differences exist between trauma-exposed individuals with and
without post-traumatic stress disorder (PTSD). It is unclear whether these epigenetic …
without post-traumatic stress disorder (PTSD). It is unclear whether these epigenetic …
Differential immune system DNA methylation and cytokine regulation in post‐traumatic stress disorder
DNA methylation may mediate persistent changes in gene function following chronic stress.
To examine this hypothesis, we evaluated African American subjects matched by age and …
To examine this hypothesis, we evaluated African American subjects matched by age and …
Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic …
OJ Watkeys, K Kremerskothen, Y Quide… - Neuroscience & …, 2018 - Elsevier
The glucocorticoid receptor gene (NR3C1) is a critical component of the stress response
system. Cytosine methylation of NR3C1 has been repeatedly associated with trauma and …
system. Cytosine methylation of NR3C1 has been repeatedly associated with trauma and …
Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder
Mindfulness Based Stress Reduction (MBSR) is an effective non-pharmacologic treatment
for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD …
for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD …
Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder
In order to determine the impact of the epigenetic response to traumatic stress on post-
traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide …
traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide …
Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy
S Wilker, V Vukojevic, A Schneider, A Pfeiffer… - Translational …, 2023 - nature.com
Epigenetic processes allow plasticity in gene regulation in response to significant
environmental events. Accumulating evidence suggests that effective psychotherapy is …
environmental events. Accumulating evidence suggests that effective psychotherapy is …
Successful treatment of post-traumatic stress disorder reverses DNA methylation marks
Epigenetic mechanisms play a role in the detrimental effects of traumatic stress and the
development of post-traumatic stress disorder (PTSD). However, it is unknown whether …
development of post-traumatic stress disorder (PTSD). However, it is unknown whether …