One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which
is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged …

It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

The growing trend for women to postpone childbearing has resulted in a dramatic increase
in the incidence of aneuploid pregnancies. Despite the importance to human reproductive …

Follicular microenvironment is paramount in the acquisition of oocyte competence, which is
dependent on two interconnected and interdependent processes: nuclear and cytoplasmic …

Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …

Aneuploidy is extremely high in aged human oocytes. Its cellular origin has been elusive.
Trisomy data implicate predominantly meiosis I errors in the genesis of oocyte aneuploidy …

Aneuploidy in human eggs increases with maternal age and can result in infertility,
miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however …

It is well documented that female fertility is decreased with advanced maternal age due to
chromosome abnormality in oocytes. Increased chromosome missegregation is mainly …

It is well established that the decline in female reproductive outcomes is related to
postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is …