[HTML][HTML] Role of substance P in cerebral edema and association with an estimated specific gravity of the brain and an outcome prediction in post-traumatic cerebral …

S Konar, D Shukla, BI Devi, R Christopher… - World Neurosurgery …, 2024 - Elsevier
Purpose The study aims to evaluate the role of substance P in cerebral edema and
outcomes associated with acute TBI. Method Patients with acute TBI who presented within 6 …

Persistently high serum substance P levels and early mortality in patients with severe traumatic brain injury

L Lorente, MM Martín, A Pérez-Cejas… - World neurosurgery, 2019 - Elsevier
Background Substance P is a neuropeptide belonging to the tachykinin family and is
involved in neuroinflammation. In a previous study by our team, we found higher serum …

Potential role of serum substance P as a favorable biomarker of functional outcome in acute spontaneous intracerebral hemorrhage

G Wang, CJ He, XS Liang, YF Zhou, SH Chen - Clinica Chimica Acta, 2020 - Elsevier
Abstract Background Substance P (SP) is implicated in brain inflammation. We clarified
relationship between serum SP concentrations and functional outcome of acute …

Serum substance P concentration in children with traumatic brain injury: a first report

Y Zhou, H Ye, W Lu - World Neurosurgery, 2021 - Elsevier
Objective To review the clinic value and severity assessment of serum substance P (SP)
concentration in children with different degrees of traumatic brain injury (TBI) through …

High serum substance P levels and mortality after malignant middle cerebral artery infarction

L Lorente, MM Martín, A Pérez-Cejas… - Journal of Critical …, 2020 - Elsevier
Purpose Previously our team found higher serum substance P concentrations at day 1 of a
malignant middle cerebral artery infarction (MMCAI) in non-surviving than in surviving …

Substance P: A novel target in the treatment of cerebral oedema and elevated intracranial pressure following traumatic brain injury

RJ Turner, R Vink - Traumatic Brain Injury, 2014 - books.google.com
Traumatic brain injury (TBI) is the biggest killer of individuals under the age of 44 years [1],
affecting over 5 million individuals worldwide each year. Many individuals are left with …

A multi-staged neuropeptide response to traumatic brain injury

JL Alves, J Mendes, R Leitão, AP Silva… - European Journal of …, 2020 - Springer
Purpose As the most abundant neuropeptides in Central Nervous System, Substance P and
Neuropeptide Y are arguably involved in the response to brain trauma. This study aims to …

Serum substance P levels and early mortality of spontaneous intracerebral haemorrhage patients

L Lorente, MM Martín, AF González-Rivero… - Journal of Stroke and …, 2020 - Elsevier
Introduction and goal Substance P, a neuropeptide of the tachykinin family, is involved in the
neuroinflammation of different diseases of the central nervous system. To our knowledge …

The role of substance P in secondary pathophysiology after traumatic brain injury

R Vink, L Gabrielian, E Thornton - Frontiers in neurology, 2017 - frontiersin.org
It has recently been shown that substance P (SP) plays a major role in the secondary injury
process following traumatic brain injury (TBI), particularly with respect to neuroinflammation …

Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury

JJ Donkin, AJ Nimmo, I Cernak… - Journal of Cerebral …, 2009 - journals.sagepub.com
Brain edema and swelling is a critical factor in the high mortality and morbidity associated
with traumatic brain injury (TBI). Despite this, the mechanisms associated with its …