DNA repair pathways, such as base excision repair, nucleotide excision repair, mismatch
repair, nonhomologous end joining and homology directed repair, play a critical role in …

DNA-repair pathways, such as base excision repair, nucleotide excision repair, mismatch
repair, nonhomologous end joining, and homology-directed repair, play a critical role in …

Tumorigenesis can be viewed as an imbalance between the mechanisms of cell-cycle
control and mutation rates within the genes. Genomic instability is broadly classified into …

Mutations in genome are essential for evolution but if the frequency of mutation increases it
can evince to be detrimental, for a steady maintenance there exist a detailed complex …

The integrity of the DNA molecule is constantly threatened by a wide range of mutagenic
agents such as pollutants, UV light, and consumed drugs. However, cells have established …

DNA repair, DNA damage tolerance and the DNA damage response are complex
biochemical events within the cell that are of critical importance with regard to genome …

The integrity of the DNA molecule is constantly threatened by a wide range of mutagenic
agents such as pollutants, UV light, and consumed drugs. However, cells have established …

DNA integrity is constantly under threat from both exogenous and endogenous DNA-
damaging agents as well as from errors that occur during DNA replication and the …

DNA damage usually happens in all cell types, which may originate from endogenous
sources (ie, DNA replication errors) or be emanated from radiations or chemicals. These …

This volume describes the elaborate surveillance systems and various DNA repair
mechanisms that ensure accurate passage of genetic information onto daughter cells. In …