p53 Promotes Ferroptosis in Macrophages Treated with Fe3O4 Nanoparticles

C Wu, Z Shen, Y Lu, F Sun, H Shi - ACS Applied Materials & …, 2022 - ACS Publications
Fe3O4 nanoparticles are the most widely used magnetic nanoparticles in the biomedicine
field. The biodistribution of most nanoparticles in vivo is determined by the capture of …

Appropriate Size of Fe3O4 Nanoparticles for Cancer Therapy by Ferroptosis

X Tian, L Ruan, S Zhou, L Wu, J Cao, X Qi… - ACS Applied Bio …, 2022 - ACS Publications
Iron oxide nanoparticles can induce cell death due to the ferroptosis mechanism, showing a
great potential for cancer therapy. Here, we synthesized different-sized iron oxide …

Time-course effect of ultrasmall superparamagnetic iron oxide nanoparticles on intracellular iron metabolism and ferroptosis activation

J Gao, H Zhou, Y Zhao, L Lu, J Zhang, W Cheng… - …, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent cell death caused by excessive peroxidation of
polyunsaturated fatty acids. It can be activated by iron-based nanoparticles as a potential …

The valence state of iron-based nanomaterials determines the ferroptosis potential in a zebrafish model

N Zheng, X Sun, Y Shi, L Chen, L Wang, H Cai… - Science of The Total …, 2023 - Elsevier
Many nanomaterials containing different valences of iron have been designed for
applications in biomedicine, energy, catalyzers, nanoenzymes, and so on. However, the …

[HTML][HTML] Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines

R Fernández-Acosta, C Iriarte-Mesa… - Molecules, 2022 - mdpi.com
The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has
reported great medical achievements. Iron-based polymeric nano-formulations with …

[HTML][HTML] High-dose exposure to polymer-coated iron oxide nanoparticles elicits autophagy-dependent ferroptosis in susceptible cancer cells

T Lomphithak, S Helvacioglu, I Armenia, S Keshavan… - Nanomaterials, 2023 - mdpi.com
Ferroptosis, a form of iron-dependent, lipid peroxidation-driven cell death, has been
extensively investigated in recent years, and several studies have suggested that the …

Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level

Z Liu, X Xia, X Lv, E Song, Y Song - Environmental Pollution, 2021 - Elsevier
Iron-bearing nanoparticles (IBNPs) were abundant in particulate matter (PM). Due to their
high reactivity, IBNPs were considered hazardous to human health, however, their toxic …

Magnetic iron oxide nanoparticles induce autophagy preceding apoptosis through mitochondrial damage and ER stress in RAW264. 7 cells

EJ Park, DH Choi, Y Kim, EW Lee, J Song, MH Cho… - Toxicology in Vitro, 2014 - Elsevier
Magnetic nanoparticles have been widely used in a broad range of disciplines owing to their
unique properties. However, many unexpected risks have been reported in their use. In this …

[HTML][HTML] Superparamagnetic iron oxide nanoparticles promote ferroptosis of ischemic cardiomyocytes

H Zheng, J You, X Yao, Q Lu, W Guo… - Journal of cellular and …, 2020 - ncbi.nlm.nih.gov
Superparamagnetic iron oxide nanoparticles (SPION) have been widely used in the
diagnosis and treatment for cardiovascular diseases. 1-6 Correspondingly, the myocardial …

Polystyrene nanoparticles reduced ROS and inhibited ferroptosis by triggering lysosome stress and TFEB nucleus translocation in a size-dependent manner

L Li, S Sun, L Tan, Y Wang, L Wang, Z Zhang… - Nano Letters, 2019 - ACS Publications
Though plastic nanoparticles have already raised much concern for their potential impact on
health, our understanding of their biological effects is still utterly limited. Here we …