Growth and maturation characterize the transition of neonates to adults. The physiological
changes that children undergo present numerous pharmacological conundrums for the …

Safe and effective drug therapy in neonates, infants and children require detailed
knowledge about the ontogeny of drug disposition and action as well how these interact with …

Safe and effective drug therapy in neonates, infants and children require detailed
knowledge about the ontogeny of drug disposition and action as well how these interact with …

Safe and efficacious drug therapy in neonates, infants and children require detailed
knowledge about the ontogeny of drug disposition and action as well how these interact with …

Abstract Anaesthesia dosing in infants (0–2 years) should be based on pharmacokinetic–
pharmacodynamic considerations and adverse effects profiles. Disease processes and …

Mechanistic models create a framework for the study of pharmacokinetic changes in infancy.
Understanding these changes allows a target concentration approach to therapy and …

Effective and safe drug administration in neonates should be based on integrated
knowledge on the evolving physiological characteristics of the infant who will receive the …

Neonatal anaesthesia dosing needs to be based on physiological characteristics of the
newborn, pharmacokinetic/pharmacodynamic considerations and the adverse effects profile …

The use of pharmacokinetic-pharmacodynamic models has improved anaesthesia practice
in children through a better understanding of dose-concentration-response relationships …

Modelling and simulation continue to have an important role optimizing drug use during
anaesthesia. Models incorporating influential covariates that better describe drug …