Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
The most significant common variant association for schizophrenia (SCZ) reflects increased
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
CUB and Sushi Multiple Domains 1 (CSMD1) opposes the complement cascade in neural tissues
Schizophrenia risk is associated with increased gene copy number and brain expression of
complement component 4 (C4). Because the complement system facilitates synaptic …
complement component 4 (C4). Because the complement system facilitates synaptic …
A transcriptome-wide association study implicates specific pre-and post-synaptic abnormalities in schizophrenia
Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth
Background Increased expression of the complement component 4A (C4A) gene is
associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in …
associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in …
The complement system: a gateway to gene–environment interactions in schizophrenia pathogenesis
VL Nimgaonkar, KM Prasad, KV Chowdari… - Molecular …, 2017 - nature.com
The pathogenesis of schizophrenia is considered to be multi-factorial, with likely gene–
environment interactions (GEI). Genetic and environmental risk factors are being identified …
environment interactions (GEI). Genetic and environmental risk factors are being identified …
Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects
Common genetic variants identified in genome-wide association studies (GWAS) show
varying degrees of genetic pleiotropy across complex human disorders. Clinical studies of …
varying degrees of genetic pleiotropy across complex human disorders. Clinical studies of …
Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia
J Gracias, F Orhan, E Hörbeck… - Nature …, 2022 - nature.com
Postsynaptic density is reduced in schizophrenia, and risk variants increasing complement
component 4A (C4A) gene expression are linked to excessive synapse elimination. In two …
component 4A (C4A) gene expression are linked to excessive synapse elimination. In two …
The complement system in schizophrenia: where are we now and what's next?
The complement system is a set of immune proteins involved in first-line defense against
pathogens and removal of waste materials. Recent evidence has implicated the complement …
pathogens and removal of waste materials. Recent evidence has implicated the complement …
Overexpression of complement component C4 in the dorsolateral prefrontal cortex, parietal cortex, superior temporal gyrus and associative striatum of patients with …
Background In schizophrenia, abnormal synaptic pruning during adolescence may be due
to altered expression of the Complement component 4 (C4). Overexpression of C4 genes …
to altered expression of the Complement component 4 (C4). Overexpression of C4 genes …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …