[HTML][HTML] Synaptic and gene regulatory mechanisms in schizophrenia, autism, and 22q11. 2 copy number variant–mediated risk for neuropsychiatric disorders
Abstract Background 22q11. 2 copy number variants are among the most highly penetrant
genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia …
genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia …
Genome‐Wide Findings in Schizophrenia and the Role of Gene–Environment Interplay
R Van Winkel, G Esquivel, G Kenis… - CNS neuroscience & …, 2010 - Wiley Online Library
The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes
M Druart, M Nosten-Bertrand, S Poll, S Crux… - Molecular …, 2021 - nature.com
Accumulating evidence supports immune involvement in the pathogenesis of schizophrenia,
a severe psychiatric disorder. In particular, high expression variants of C4, a gene of the …
a severe psychiatric disorder. In particular, high expression variants of C4, a gene of the …
Genome-wide association analysis of Parkinson's disease and schizophrenia reveals shared genetic architecture and identifies novel risk loci
Background Parkinson's disease (PD) and schizophrenia (SCZ) are heritable brain
disorders that involve dysregulation of the dopaminergic system. Epidemiological studies …
disorders that involve dysregulation of the dopaminergic system. Epidemiological studies …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …
shifting clinical phenomena across the life span. We investigated the convergence of …
The association between schizophrenia and the immune system: Review of the evidence from unbiased 'omic-studies'
HC van Mierlo, A Schot, MPM Boks, LD de Witte - Schizophrenia research, 2020 - Elsevier
A role for immune processes in the pathogenesis of schizophrenia has been suggested by
genetic and epidemiological studies, as well as cross-sectional studies on blood and brain …
genetic and epidemiological studies, as well as cross-sectional studies on blood and brain …
[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?
J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …
conferring risk to the disorder. This progress offers an important route toward defining the …
Neuronal cell adhesion genes: key players in risk for schizophrenia, bipolar disorder and other neurodevelopmental brain disorders?
AP Corvin - Cell adhesion & migration, 2010 - Taylor & Francis
The major mental disorders, schizophrenia and bipolar disorder are substantially heritable.
Recent genomic studies have identified a small number of common and rare risk genes …
Recent genomic studies have identified a small number of common and rare risk genes …
Multifaceted genomic risk for brain function in schizophrenia
Recently, deriving candidate endophenotypes from brain imaging data has become a
valuable approach to study genetic influences on schizophrenia (SZ), whose …
valuable approach to study genetic influences on schizophrenia (SZ), whose …
Protein-protein interaction and pathway analyses of top schizophrenia genes reveal schizophrenia susceptibility genes converge on common molecular networks and …
Recent genome-wide association studies have identified many promising schizophrenia
candidate genes and demonstrated that common polygenic variation contributes to …
candidate genes and demonstrated that common polygenic variation contributes to …