Most simian immunodeficiency viruses (SIVs) use Nef to counteract restriction by the tetherin
proteins of their nonhuman primate hosts. In addition to counteracting tetherin, SIV Nef has a …

Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize
human tetherin to promote viral release and replication. We show that Vpus from SIVgsn …

Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize
human tetherin to promote viral release and replication. We find that Vpus from SIVgsn …

The mammalian antiviral membrane protein tetherin (BST2/CD317) can be expressed as
two isoforms derived from differential translational initiation. The shorter isoform of the …

Tetherin, also known as BST2, CD317 or HM1. 24, was recently identified as an interferon-
inducible host–cell factor that interferes with the detachment of virus particles from infected …

Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their
nonhuman primate hosts. Nef also downmodulates cell-surface CD4 and MHC class I (MHC …

Tetherin is a host defense factor that physically prevents virion release from the plasma
membrane. The Nef accessory protein of simian immunodeficiency virus (SIV) engages the …

In different primate lentiviruses, three proteins (Vpu, Env and Nef) have been shown to have
anti-tetherin activities. SIVden is a primate lentivirus harbored by a Cercopithecus denti (C …

Nef is the viral gene product employed by the majority of primate lentiviruses to overcome
restriction by tetherin (BST-2 or CD317), an interferon-inducible transmembrane protein that …

The multifunctional Nef protein of primate lentiviruses is commonly considered an early viral
factor that downmodulates various receptors from the cell surface and modulates several …