Background A new subgroup of HIV-1, designated Group P, was recently detected in two
unrelated patients of Cameroonian origin. HIV-1 Group P phylogenetically clusters with …

Tetherin prevents viral cross-species transmission by inhibiting the release of multiple
enveloped viruses from infected cells. With the evolution of simian immunodeficiency virus of …

Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first
observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected …

ABSTRACT Tetherin (CD317/BST-2), an interferon-induced membrane protein, restricts the
release of nascent retroviral particles from infected cell surfaces. While human …

Background HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite
the same genomic organization, only the group M viruses are responsible for the world-wide …

Summary Tetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that
inhibits virus release from infected cells. Whereas HIV-1 Vpu and HIV-2 Env counteract …

ABSTRACT Tetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein
that inhibits virus release from infected cells. To determine the extent of sequence variation …

Direct cell-to-cell spread of human immunodeficiency virus type 1 (HIV-1) between T cells at
the virological synapse (VS) is an efficient mechanism of viral dissemination. Tetherin (BST …

Background: Cell-mediated immune (CMI) responses are critical for the control of HIV-1
infection and their importance was highlighted by the existence of viral proteins, particularly …

Tetherin is an IFN-inducible restriction factor that inhibits HIV-1 particle release in the
absence of the HIV-1 countermeasure, viral protein U (Vpu). Although ubiquitous in HIV-1 …