Neurotrophic factors (NTFs) are endogenous polypeptides that regulate the growth, survival,
differentiation, and functioning of neurons. The neuroprotective effects of NTFs in …

The neurotrophin Nerve Growth Factor (NGF) holds a great potential as a therapeutic
candidate for the treatment of neurological diseases. However, its safe and effective delivery …

Neurotrophic factors are proteins with considerable potential in the treatment of central
nervous system (CNS) diseases and traumatic injuries. However, a significant challenge to …

Introduction: Among the range of therapeutic protein candidates for new generation
treatments of neurological diseases, neurotrophic factors and recombinant antibodies hold …

Injury to the central nervous system (CNS) generally results in significant neuronal death
and functional loss. In vitro experiments have demonstrated that neurotrophic factors such …

Since the 1980s, the development of a pharmacology based on nerve growth factor (NGF)
has been postulated for the therapy of Alzheimer's disease (AD). This hypothesis was based …

Brain‐derived neurotrophic factor (BDNF) is identified as a potent neuroprotective and
neuroregenerative agent for many neurological diseases. Regrettably, its delivery to the …

One of the most challenging problems facing modern medicine is how to deliver a given
drug to a specific target at the exclusion of other regions. For example, a variety of …

Introduction: The blood–brain barrier (BBB) is like an iron curtain that prevents exogenous
substances, including most drugs, from entering the CNS. Intranasal delivery has been …

While enormous progress has been made regarding our understanding of the pathogenic
mechanisms of neurological diseases, there are only a small number of effective drugs for …