OBJECTIVE Ischemic stroke may result from transient or permanent reductions of regional
cerebral blood flow. Polymorphonuclear neutrophils have been described as the earliest …

This study sought to identify potential targets for acute stroke therapy that can be exploited
pharmacologically beyond the current 4.5 h time limit for clinical administration of …

Inflammation-related cerebral damage mediated by infiltrating neutrophils following
reperfusion plays a role in reperfusion-induced brain damage subsequent to a stroke event …

Leukocyte infiltration is viewed as a pharmacological target in cerebral ischemia. We
previously reported that reparixin, a CXCL8 receptor blocker that inhibits neutrophil …

Cerebral ischemia–reperfusion injury is associated with a developing inflammatory
response with pathologic contributions from vascular leukocytes and endogenous microglia …

Background and Purpose—Inflammatory response plays a critical role in propagating tissue
damage after focal cerebral ischemia. CXCL12 is a key chemokine for leukocyte recruitment …

Stroke is the second cause of mortality worldwide and occurs following the interruption of
cerebral blood circulation by cerebral vessel burst or subsequent to a local thrombus …

Background and Purpose—The chemokine, monocyte chemoattractant protein-1 (CCL2), is
a major factor driving leukocyte infiltration into the brain parenchyma in a variety of …

Intracerebral hemorrhage (ICH) is a major cause of stroke, with high mortality and morbidity.
There is no effective pharmacological therapy for ICH. Previous studies have indicated that …

Ischemic stroke involves a series of complex pathological mechanisms, of which
neuroinflammation is currently the most widely recognized. C–C motif chemokine receptor 5 …