Blood-brain Barrier and Neurovascular Unit Dysfunction in Parkinson's Disease: From Clinical Insights to Pathogenic Mechanisms and Novel Therapeutic Approaches

SLQ Khor, KY Ng, RY Koh… - CNS & Neurological …, 2024 - ingentaconnect.com
The blood-brain barrier (BBB) plays a crucial role in the central nervous system by tightly
regulating the influx and efflux of biological substances between the brain parenchyma and …

[HTML][HTML] Neurovascular unit dysfunction and neurodegenerative disorders

X Yu, C Ji, A Shao - Frontiers in neuroscience, 2020 - frontiersin.org
The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the
minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier …

[HTML][HTML] Blood-brain barrier dysfunction in CNS disorders and putative therapeutic targets: an overview

SR Archie, A Al Shoyaib, L Cucullo - Pharmaceutics, 2021 - mdpi.com
The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

[HTML][HTML] Microvascular changes in Parkinson's disease-focus on the neurovascular unit

G Paul, OF Elabi - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Vascular alterations emerge as a common denominator for several neurodegenerative
diseases. In Parkinson's disease (PD), a number of observations have been made …

[HTML][HTML] Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease

R Cabezas, M Ávila, J Gonzalez… - Frontiers in cellular …, 2014 - frontiersin.org
The blood–brain barrier (BBB) is a tightly regulated interface in the Central Nervous System
(CNS) that regulates the exchange of molecules in and out from the brain thus maintaining …

[HTML][HTML] A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity

C Barberio, A Withers, Y Mishra… - Frontiers in Cellular …, 2022 - frontiersin.org
The blood-brain barrier (BBB) restricts paracellular and transcellular diffusion of compounds
and is part of a dynamic multicellular structure known as the 'neurovascular unit'(NVU) …

Blood–brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy

BS Desai, AJ Monahan, PM Carvey… - Cell …, 2007 - journals.sagepub.com
The blood–brain barrier (BBB) is a tightly regulated barrier in the central nervous system.
Though the BBB is thought to be intact during neurodegenerative diseases such as …

[PDF][PDF] Disruption of the blood-brain barrier in Parkinson's disease: curse or route to a cure

H Lee, IS Pienaar - Front Biosci (Landmark Ed), 2014 - article.imrpress.com
[Frontiers in Bioscience 19, 272-280, January 1, 2014] 272 Disruption of the blood-brain barrier
in parkinson’s disease: curse Page 1 [Frontiers in Bioscience 19, 272-280, January 1, 2014] 272 …

[HTML][HTML] Blood-brain barrier: from physiology to disease and back

MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

[HTML][HTML] Blood-brain barrier: more contributor to disruption of central nervous system homeostasis than victim in neurological disorders

M Xiao, ZJ Xiao, B Yang, Z Lan, F Fang - Frontiers in Neuroscience, 2020 - frontiersin.org
The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular
system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by …