Natural Killer (NK) cells are cytotoxic lymphocytes that play a key role in the immune system,
targeting and destroying invading pathogens and malignantly transformed cells. Evading NK …

The increase of cell surface sialic acid is a characteristic shared by many tumor types. A
correlation between hypersialylation and immunoprotection has been observed, but few …

Simple Summary Hyperglycosylated cancer cells are often decorated with abundant sialic
acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) …

Alteration of the surface glycosylation pattern on malignant cells potentially affects tumor
immunity by directly influencing interactions with glycan-binding proteins (lectins) on the …

Sialic acids represent a family of sugar molecules derived from neuraminic acid that
frequently terminate glycan chains and contribute to many biological processes. Already five …

Sialic acid-binding immunoglobulin-like lectins, also known as Siglecs, have recently been
designated as glyco-immune checkpoints. Through their interactions with sialylated glycan …

The function of natural killer (NK) cells, defending against virus infection and tumour
progression, is regulated by multiple activating and inhibiting receptors expressed on NK …

Abstract Changes in sialic acids in cancer have been observed for many years. In particular,
the increase of sialoglycan density or hypersialylation in tumors has been described. Recent …

Chimeric antigen receptor (CAR) T‐cells treatment demonstrate the increasing and powerful
potential of immunotherapeutic strategies, as seen mainly for hematological malignancies …

Many Siglecs function as inhibitory receptors on innate and adaptive immune cells and may
contribute to the attenuation of immune responses to tumors. Siglec 9 on neutrophils and …