Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in
humans, including immune cells and their target cells, with various functions. Natural Killer …

Siglecs are widely expressed on leucocytes and bind to ubiquitously presented glycans
containing sialic acids (sialoglycans). Most Siglecs carry an immunoreceptor tyrosine‐based …

Abstract Changes in glycosylation during tumour progression are a key hallmark of cancer.
One of the glycan moieties generally overexpressed in cancer are sialic acids, which can …

Upregulation of surface expressed sialoglycans on tumor cells is one of the mechanisms
which promote tumor growth and progression. Specifically, the interactions of sialic acids …

Cancers utilize glycans to evade the immune system via the Sialic acid (Sia)-Siglec (Sialic-
acid-binding immunoglobulin-like lectins) pathway. Specifically, atypical structural forms of …

Abnormal glycosylation is a hallmark of cancer, and the hypersialylated tumor cell surface
facilitates abnormal cell trafficking and drug resistance in several malignancies, including …

Siglecs (sialic acid–binding immunoglobulin-like lectins) are a family of receptors that bind
sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in …

Siglec-7 is a human CD33-like siglec, and is localised predominantly on human natural
killer (NK) cells and monocytes. Siglec-7 is considered to function as an immunoreceptor in …

Introduction: During cancer progression, tumor cells develop several mechanisms to prevent
killing and to shape the immune system into a tumor-promoting environment. One of such …

Sialic acid sugars on the surface of cancer cells have emerged as potent immune
modulators that contribute to the immunosuppressive microenvironment and tumor immune …