Objectives. Research studies have reported impressive antidepressant effects with ketamine
but significant knowledge gaps remain over the best method of administering ketamine, and …

Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …

Background Little is known about the antidepressive effects of repeated intravenous
ketamine infusions beyond the acute phase of treatment in patients with refractory …

Objective: Ketamine has demonstrated rapid antidepressant effects in patients with
treatment-resistant depression (TRD); however, the safety and tolerability of ketamine in this …

Introduction Ketamine treatment is capable of significant and rapid symptom improvement in
adults with treatment-resistant depression (TRD). A limitation of ketamine treatment in TRD …

Background: Ketamine, administered in subanesthetic doses, is an effective off-label
treatment for severe and even treatment-refractory depression; however, despite dozens of …

BackgroundKetamine has been demonstrated to improve depressive symptoms.
AimsEvaluation of efficacy, safety and feasibility of repeated oral ketamine for out-patients …

Background Due to unmet clinical needs for efficient drugs with a rapid onset of
antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different …

OBJECTIVE: To evaluate the literature regarding the efficacy and safety of intravenous
ketamine for treatment-resistant major depressive disorder (MDD). DATA SOURCES: A …

Since publication of the first randomized controlled trial describing rapid antidepressant
effects of ketamine, several reports have confirmed the potential utility of this dissociative …