A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes
BackgroundThere is growing interest in glutamatergic agents in depression, particularly
ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist. We aimed to …
ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist. We aimed to …
The antidepressant effect of ketamine is dampened by concomitant benzodiazepine medication
V Andrashko, T Novak, M Brunovsky, M Klirova… - Frontiers in …, 2020 - frontiersin.org
The rapid antidepressant effect of ketamine has become a breakthrough in the research and
treatment of depression. Although predictive and modulating factors of the response to …
treatment of depression. Although predictive and modulating factors of the response to …
Ketamine for treatment‐resistant unipolar and bipolar major depression: Critical review and implications for clinical practice
WV Bobo, JL Vande Voort, PE Croarkin… - Depression and …, 2016 - Wiley Online Library
There is an urgent need for more rapidly effective pharmacotherapies for major depressive
disorder and bipolar disorder (BP) that are efficacious and tolerable for depressed patients …
disorder and bipolar disorder (BP) that are efficacious and tolerable for depressed patients …
[HTML][HTML] Ketamine for depression, 1: clinical summary of issues related to efficacy, adverse effects, and mechanism of action
C Andrade - The Journal of clinical psychiatry, 2017 - psychiatrist.com
Ketamine is an anesthetic drug that is also used for off-label indications such as the
mediation of analgesia and sedation in various settings. It is additionally recognized as an …
mediation of analgesia and sedation in various settings. It is additionally recognized as an …
[HTML][HTML] Ketamine for depression, 5: potential pharmacokinetic and pharmacodynamic drug interactions
C Andrade - The Journal of Clinical Psychiatry, 2017 - legacy.psychiatrist.com
Ketamine, administered in subanesthetic doses, is gaining recognition as an off-label
treatment for severe and even treatment-refractory depression. This article explores potential …
treatment for severe and even treatment-refractory depression. This article explores potential …
Acute and longer-term outcomes using ketamine as a clinical treatment at the Yale Psychiatric Hospital
ST Wilkinson, RB Katz, M Toprak… - The Journal of clinical …, 2018 - psychiatrist.com
Objective: Ketamine has emerged as a rapid-acting antidepressant, though controversy
remains whether sufficient data exist to justify its use outside of research protocols. In …
remains whether sufficient data exist to justify its use outside of research protocols. In …
Rapid and longer-term antidepressant effects of repeated-dose intravenous ketamine for patients with unipolar and bipolar depression
W Zheng, YL Zhou, WJ Liu, CY Wang, YN Zhan… - Journal of psychiatric …, 2018 - Elsevier
Objective Single-dose intravenous (IV) injection of ketamine has shown rapid but transient
antidepressant effects. The strategy of repeated-dose ketamine infusions to maintain …
antidepressant effects. The strategy of repeated-dose ketamine infusions to maintain …
Placebo‐controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression
CK Loo, V Gálvez, E O'Keefe… - Acta Psychiatrica …, 2016 - Wiley Online Library
Objective This pilot study assessed the feasibility, efficacy and safety of an individual dose‐
titration approach, and of the intravenous (IV), intramuscular (IM) and subcutaneous (SC) …
titration approach, and of the intravenous (IV), intramuscular (IM) and subcutaneous (SC) …
Ketamine and depression: a narrative review
A Corriger, G Pickering - Drug design, development and therapy, 2019 - Taylor & Francis
Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …
be reduced within several weeks after the start of conventional antidepressants, but …
Administration of ketamine for unipolar and bipolar depression
C Kraus, U Rabl, T Vanicek, L Carlberg… - … journal of psychiatry …, 2017 - Taylor & Francis
Objective: Clinical trials demonstrated that ketamine exhibits rapid antidepressant efficacy
when administered in subanaesthetic dosages. We reviewed currently available literature …
when administered in subanaesthetic dosages. We reviewed currently available literature …