[HTML][HTML] Fabrication of active targeting lipid nanoparticles: Challenges and perspectives

I Menon, M Zaroudi, Y Zhang, E Aisenbrey… - Materials Today Advances, 2022 - Elsevier
Targeted drug and gene delivery is the key for precision therapy. Lipid nanoparticles as non-
viral vectors have attracted extensive attentions in treating a variety of diseases, such as …

Solid lipid nanoparticles: a versatile approach for controlled release and targeted drug delivery

M Munir, M Zaman, MA Waqar, MA Khan… - Journal of Liposome …, 2024 - Taylor & Francis
Abstract Solid Lipid Nanoparticles (SLN), the first type of lipid-based solid carrier systems in
the nanometer range, were introduced as a replacement for liposomes. SLN are aqueous …

Properties, engineering and applications of lipid-based nanoparticle drug-delivery systems: current research and advances

J Buse, A El-Aneed - Nanomedicine, 2010 - Taylor & Francis
Lipid-based drug-delivery systems have evolved from micro-to nano-scale, enhancing the
efficacy and therapeutic applications of these delivery systems. Production of lipid-based …

[HTML][HTML] Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

Y Li, Z Ye, H Yang, Q Xu - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically
advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of …

[HTML][HTML] Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects

S Scioli Montoto, G Muraca, ME Ruiz - Frontiers in molecular …, 2020 - frontiersin.org
In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of
the original concepts and ideas. There is no doubt that nanoformulations are extremely …

Lipid nanoparticles for cell-specific in vivo targeted delivery of nucleic acids

IA Khalil, MA Younis, S Kimura… - Biological and …, 2020 - jstage.jst.go.jp
The last few years have witnessed a great advance in the development of nonviral systems
for in vivo targeted delivery of nucleic acids. Lipid nanoparticles (LNPs) are the most …

[PDF][PDF] Solid lipid nanoparticles–a review

MK Sarangi, S Padhi - drugs, 2016 - researchgate.net
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology
with several potential applications in drug delivery, clinical medicine, and research, as well …

Chemistry and art of developing lipid nanoparticles for biologics delivery: focus on development and scale-up

R John, J Monpara, S Swaminathan, R Kalhapure - Pharmaceutics, 2024 - mdpi.com
Lipid nanoparticles (LNPs) have gained prominence as primary carriers for delivering a
diverse array of therapeutic agents. Biological products have achieved a solid presence in …

Lipid-based nanoparticles for drug/gene delivery: An overview of the production techniques and difficulties encountered in their industrial development

M Mehta, TA Bui, X Yang, Y Aksoy, EM Goldys… - ACS Materials …, 2023 - ACS Publications
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery
systems complementing conventional pharmacology has been widely acknowledged …

Solid lipid nanoparticles for targeting and delivery of drugs and genes

RK Tekade, R Maheshwari, M Tekade… - … -based approaches for …, 2017 - Elsevier
Most of the biologically active compounds are struggle with low solubility and therefore low
bioavailability, biological degradation and inadvertent intrinsic side effects. To overcome …