To better understand TCR discrimination of multiple ligands, we have analyzed the crystal
structures of two Hb peptide/IE k complexes that differ by only a single amino acid …

Abstract The HLA‐A* 02: 01‐restricted decapeptide EAAGIGILTV, derived from melanoma
antigen recognized by T‐cells‐1 (MART‐1) protein, represents one of the best‐studied …

MHC anchor residue‐modified “heteroclitic” peptides have been used in many cancer
vaccine trials and often induce greater immune responses than the wild‐type peptide. The …

We investigated mechanistic differences in antigen presentation between murine MHC class
I variants H-2K (b) and H-2K (bm) 8. H-2K (bm) 8 differs from H-2K (b) by four residues at the …

We report the creation of TCR partial agonists by the novel approach of manipulating the
interaction between immunogenic peptide and MHC. Amino acids at MHC anchor positions …

The immune system has developed a variety of mecharmisms for sensing the presence of
invading microorganisms, which must be accomplished in the face of special topological …

The TCR recognition of peptides bound to MHC class II molecules is highly flexible in some
T cells. Although progress has been made in understanding the interactions within the …

Recombinant αβ T cell receptors, expressed on T cell membranes, recognize short peptides
presented at the cell surface in complex with MHC molecules. There are two main subsets of …

T cells recognize MHC-bound peptide, suggesting that the TCR contacts surface MHC
residues adjacent to bound peptide, but the extent of MHC contact is not known. T cells also …

Although conformational changes in TCRs and peptide Ags presented by MHC protein
(pMHC) molecules often occur upon binding, their relationship to intrinsic flexibility and role …