[HTML][HTML] PPA1 promotes breast cancer proliferation and metastasis through PI3K/AKT/GSK3β signaling pathway

C Guo, S Li, A Liang, M Cui, Y Lou… - Frontiers in Cell and …, 2021 - frontiersin.org
Breast cancer is the most common malignancy among women. Inorganic pyrophosphatase
1 (PPA1) is a multifunctional protein involved in the development of several tumors …

[HTML][HTML] Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway

H Niu, W Zhou, Y Xu, Z Yin, W Shen, Z Ye, Y Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic
pyrophosphate levels, and its expression is correlated with growth of several solid tumors …

[HTML][HTML] PPA1 regulates tumor malignant potential and clinical outcome of colon adenocarcinoma through JNK pathways

P Wang, Y Zhou, Q Mei, J Zhao, L Huang, Q Fu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) represents one of the most prevalent malignancies and the third
leading cause of cancer death worldwide. Inorganic pyrophosphatase (PPA1) is an enzyme …

[HTML][HTML] PPA1 promotes NSCLC progression via a JNK-and TP53-dependent manner

D Luo, D Liu, W Shi, H Jiang, W Liu, X Zhang, Y Bao… - Oncogenesis, 2019 - nature.com
Inorganic pyrophosphatase (PPA1) promotes tumor progression in several tumor types.
However, the underlying mechanism remains elusive. Here, we disclosed that PPA1 …

[HTML][HTML] Identification of critical elements for regulation of inorganic pyrophosphatase (PPA1) in MCF7 breast cancer cells

DR Mishra, S Chaudhary, BM Krishna, SK Mishra - PLoS One, 2015 - journals.plos.org
Cytosolic inorganic pyrophosphatase plays an important role in the cellular metabolism by
hydrolyzing inorganic pyrophosphate (PPi) formed as a by-product of various metabolic …

[HTML][HTML] PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors

S Wang, J Wei, S Li, Y Luo, Y Li, X Wang… - Frontiers in …, 2022 - frontiersin.org
Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble
Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo …

[HTML][HTML] PP2A as a potential therapeutic target for breast cancer: Current insights and future perspectives

Y Qi, L Li, Y Wei, F Ma - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Breast cancer has become the most prevalent malignancy worldwide; however, therapeutic
efficacy is far from satisfactory. To alleviate the burden of this disease, it is imperative to …

[HTML][HTML] PPP2R2D, a regulatory subunit of protein phosphatase 2A, promotes gastric cancer growth and metastasis via mechanistic target of rapamycin activation

S Yu, L Li, Q Wu, N Dou, Y Li… - … Journal of Oncology, 2018 - spandidos-publications.com
Abstract Protein phosphatase 2A (PP2A) is an essential serine/threonine protein
phosphatase that regulates the basic activities of eukaryotes by dephosphorylating its …

Clinical significance and functional validation of PPA1 in various tumors

D Luo, G Wang, W Shen, S Zhao, W Zhou… - Cancer …, 2016 - Wiley Online Library
The aim of the study was to detect PPA 1 expression in various tumors and to investigate the
relationship between PPA 1 expression and clinicopathological parameters to further …

Expression of inorganic pyrophosphatase (PPA1) correlates with poor prognosis of epithelial ovarian cancer

H Li, N Xiao, Z Li, Q Wang - The Tohoku journal of experimental …, 2017 - jstage.jst.go.jp
Ovarian serous carcinoma (OSC) is the most common epithelial ovarian cancer. Inorganic
pyrophosphatase (PPA1) catalyzes the hydrolysis of pyrophosphate to inorganic phosphate …